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首页> 外文期刊>Tropical Animal Health and Production >Spoligotype diversity and 5-year trends of bovine tuberculosis in Extremadura, southern Spain
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Spoligotype diversity and 5-year trends of bovine tuberculosis in Extremadura, southern Spain

机译：西班牙南部埃斯特雷马杜拉的Spoligotype多样性和牛结核病的5年趋势

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摘要

Bovine tuberculosis (bTB) causes significant losses to farming economies worldwide. A better understanding on the epidemiology of this disease and the role that the different hosts develop in the maintenance and spread of bTB is vital to control this zoonotic disease. This study reports the spoligotype diversity and temporal evolution of Mycobacterium tuberculosis Complex (MTBC) isolates obtained from Extremadura (southern Spain). Genotyping data of Mycobacterium bovis (n = 2102) and Mycobacterium caprae (n = 96) isolates from cattle and wildlife species, collected between 2008 and 2012, were used in this study. The isolates resulted clustered into 88 spoligotypes which varied largely in frequency and occurrence in the three hosts. The 20 most frequent patterns represented 91.99 % of the isolates, the spoligotype SB0121 being the clearly predominant and most widely dispersed geographically. The major variety of the spoligotype patterns (78 out of 88) was isolated from the cattle, in fact 50 (56.83 %) of the patterns were found only in this species. Within the spoligotypes shared between the cattle and wildlife species, 17 patterns (1747 isolates) were shared with wild boar and Iberian red deer, 10 patterns (308 isolates) were exclusively shared with wild boar, and only one pattern (two isolates) was shared exclusively with Iberian red deer. The significant number of spoligotypes shared between the three hosts (79.49 %) highlights the components of the multi-host system that allows the bTB maintenance in our study area. The greater percentage of isolates shared by the wild boar and cattle (93.50 %) supports the role of wild boar as main maintenance host for bTB in cattle. These results could be extrapolated to areas with a similar epidemiological scenario and could be helpful for other countries where wild reservoirs represent a handicap for the successful eradication of bTB from livestock.
机译：牛结核病（bTB）对全世界的农业经济造成了重大损失。更好地了解这种疾病的流行病学以及不同宿主在bTB的维持和传播中发挥的作用对于控制这种人畜共患病至关重要。这项研究报告了从埃斯特雷马杜拉（西班牙南部）获得的结核分枝杆菌复合体（MTBC）分离株的spoligotype多样性和时间演变。在这项研究中，使用了牛和野生动物物种的牛分枝杆菌（n = 2102）和卡普拉分枝杆菌（n = 96）分离株的基因分型数据。结果表明，这些分离物聚集成了88个spoligotype，在三个宿主中的频率和发生率差异很大。 20个最常见的模式代表了91.99％的分离株，其中spoligotype SB0121是最明显且分布最广泛的地理区域。从牲畜中分离出主要的血吸虫型模式（88种中有78种），实际上仅在该物种中发现了50种（56.83％）。在牛和野生动物之间共有的血吸型中，野猪和伊比利亚马鹿共有17种模式（1747株），野猪仅共享10种模式（308株），而只有一种模式（2种）被共享只与伊比利亚马鹿一起。三台主机之间共享的大量spoligotypes（79.49％）突出显示了多主机系统的组件，该组件允许在我们的研究区域中维护bTB。野猪和牛共有的分离株比例更高（93.50％），支持野猪作为牛bTB的主要维持宿主。这些结果可以外推到流行病学类似的地区，并且对于其他国家，那里的野生水库是成功地从牲畜中消灭bTB的障碍，可能会有所帮助。

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