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Experimental evidence for sparse firing in the neocortex

机译:新皮质稀疏射击的实验证据

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The advent of unbiased recording and imaging techniques to evaluate firing activity across neocortical neurons has revealed substantial heterogeneity in response properties in vivo, and that a minority of neurons are responsible for the majority of spikes. Despite the computational advantages to sparsely firing populations, experimental data defining the fraction of responsive neurons and the range of firing rates have not been synthesized. Here we review data about the distribution of activity across neuronal populations in primary sensory cortex. Overall, the firing output of granular and infragranular layers is highest. Although subthreshold activity across supragranular neurons is decidedly non-sparse, spikes are much less frequent and some cells are silent. Superficial layers of the cortex may employ specific cell and circuit mechanisms to increase sparseness.
机译:用于评估跨新皮层神经元的放电活动的无偏记录和成像技术的出现揭示了体内响应特性的显着异质性,并且少数神经元负责大多数尖峰信号。尽管稀疏放电种群具有计算优势,但尚未合成定义反应性神经元分数和放电速率范围的实验数据。在这里,我们审查有关初级感觉皮层神经元人口活动分布的数据。总体而言,颗粒层和颗粒下层的烧结产量最高。尽管跨上神经元的亚阈值活动无疑是不稀疏的,但尖峰的发生频率要低得多,一些细胞却保持沉默。皮质的表层可以采用特定的细胞和电路机制来增加稀疏性。

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