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首页> 外文期刊>Trends in Neurosciences >How do the basal ganglia regulate sleep-wake behavior?
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How do the basal ganglia regulate sleep-wake behavior?

机译:基底神经节如何调节睡眠-觉醒行为?

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摘要

The basal ganglia (BG) are involved in motor function, habit formation, and reward or addictive behaviors, but the question as to how the BG integrate arousal with these fundamental striatal functions has only recently received much attention. Findings based on electrophysiology, neurotoxic lesioning, and the use of transgenic animals have established that the striatum and globus pallidus are key structural elements for the control of sleep and wakefulness. Here, we discuss emerging anatomical and molecular mechanisms of sleep-wake regulation at work in the BG. Furthermore, we propose a model whereby adenosine and dopamine receptors in the nucleus accumbens (NAc) are involved in the integration of behavioral processes and the induction of wakefulness through cortical activation.
机译:基底神经节(BG)参与运动功能,习惯养成以及奖赏或上瘾行为,但是关于BG如何将唤醒与这些基本纹状体功能整合在一起的问题直到最近才受到关注。基于电生理学,神经毒性损害和转基因动物的使用的发现已经确定纹状体和苍白球是控制睡眠和清醒的关键结构要素。在这里,我们讨论了BG工作中新兴的睡眠-唤醒调节的解剖学和分子机制。此外,我们提出了一个模型,其中伏伏核(NAc)中的腺苷和多巴胺受体参与行为过程的整合和通过皮层激活诱导清醒。

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