...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Trends in Neurosciences >Mitochondria as a central sensor for axonal degenerative stimuli
【24h】

Mitochondria as a central sensor for axonal degenerative stimuli

机译：线粒体作为轴突退行性刺激的中央传感器。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Axonal degeneration is a major contributor to neuronal dysfunction in many neurological conditions and has additional roles in development. It can be triggered by divergent stimuli including mechanical, metabolic, infectious, toxic, hereditary and inflammatory stresses. Axonal mitochondria are an important convergence point as regulators of bioenergetic metabolism, reactive oxygen species (ROS), Ca 2+ homeostasis and protease activation. The challenges likely to render axonal mitochondria more vulnerable than their cellular counterparts are reviewed, including axonal transport, replenishing nuclear-encoded proteins and maintenance of quality control, fusion and fission in locations remote from the cell body. The potential for mitochondria to act as a decision node in axon loss is considered, highlighting the need to understand the biology of axonal mitochondria and their contributions to degenerative mechanisms for novel therapeutic strategies.
机译：轴突变性是许多神经系统疾病中神经元功能障碍的主要因素，并且在发育中还具有其他作用。它可以由不同的刺激触发，包括机械，代谢，传染性，毒性，遗传性和炎症性应激。轴突线粒体是生物能量代谢，活性氧（ROS），Ca 2+稳态和蛋白酶激活的调节剂，是一个重要的融合点。审查了可能使轴突线粒体比其细胞对应物更脆弱的挑战，包括轴突运输，补充核编码蛋白以及在远离细胞体的位置维持质量控制，融合和裂变。考虑到线粒体在轴突丧失中作为决策节点的潜力，这突出了了解轴突线粒体生物学及其对新治疗策略的退化机制的贡献的必要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号