New perspectives on neuronal development via microfluidic environments

MilletL.J.; GilletteM.U.

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New perspectives on neuronal development via microfluidic environments

机译：通过微流环境神经元发展的新观点

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Understanding the signals that guide neuronal development and direct formation of axons, dendrites, and synapses during wiring of the brain is a fundamental challenge in developmental neuroscience. Discovery of how local signals shape developing neurons has been impeded by the inability of conventional culture methods to interrogate microenvironments of complex neuronal cytoarchitectures, where different subdomains encounter distinct chemical, physical, and fluidic features. Microfabrication techniques are facilitating the creation of microenvironments tailored to neuronal structures and subdomains with unprecedented access and control. The design, fabrication, and properties of microfluidic devices offer significant advantages for addressing unresolved issues of neuronal development. These high-resolution approaches are poised to contribute new insights into mechanisms for restoring neuronal function and connectivity compromised by injury, stress, and neurodegeneration.

机译：理解指导神经元发育以及在大脑布线期间直接形成轴突，树突和突触的信号是发育神经科学的一项基本挑战。传统培养方法无法询问复杂的神经元细胞结构的微环境，阻碍了局部信号如何塑造发育中的神经元的发现，在复杂的神经元细胞结构中，不同的子域遇到不同的化学，物理和流体特征。微制造技术正在促进针对神经元结构和子域量身定制的微环境的创建，并具有前所未有的访问和控制能力。微流体装置的设计，制造和性能为解决神经元发育未解决的问题提供了显着的优势。这些高分辨率方法有望为恢复因损伤，压力和神经退行性变而受损的神经元功能和连通性的机制提供新见解。

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《Trends in Neurosciences》 |2012年第12期|共10页
作者
MilletL.J.; GilletteM.U.;
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正文语种 eng
中图分类神经病学;
关键词
Axon guidance; Dendrite; Developmental neuroscience; Microfluidic devices; Neuronal polarity; Synapse;

机译：轴突导向;树突;发育神经科学;微流控装置;神经元极性;突触;

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1. New perspectives on neuronal development via microfluidic environments [J] . MilletL.J., GilletteM.U. Trends in Neurosciences . 2012,第12期

机译：通过微流环境神经元发展的新观点
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4. Neuronal differentiation of mouse embryonic stem cells using microfluidic spatial confinement of cell parts and soluble factors [C] . Dixon A.R., Anthony T., Ramirez Y., 2014 40th Annual Northeast Bioengineering Conference . 2014

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5. Development, maturation, and perturbation of neuronal networks and applications of a synaptic signal on neuronal and neuromuscular development. [D] . Zemianek, Jill. 2013

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6. New perspectives on neuronal development via microfluidic environments [O] . Larry J. Millet, Martha U. Gillette -1

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7. Development of primary neuronal culture of embryonic rabbit dorsal root ganglia for microfluidic chamber analysis of axon mediated neuronal spread of Bovine Herpesvirus type 1. [O] . Coats Charles Jason 100

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New perspectives on neuronal development via microfluidic environments

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