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首页> 外文期刊>Trends in Neurosciences >Brainstem respiratory networks: Building blocks and microcircuits
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Brainstem respiratory networks: Building blocks and microcircuits

机译:脑干呼吸网络:构件和微电路

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摘要

Breathing movements in mammals are driven by rhythmic neural activity generated within spatially and functionally organized brainstem neural circuits comprising the respiratory central pattern generator (CPG). This rhythmic activity provides homeostatic regulation of gases in blood and tissues and integrates breathing with other motor acts. We review new insights into the spatial-functional organization of key neural microcircuits of this CPG from recent multidisciplinary experimental and computational studies. The emerging view is that the microcircuit organization within the CPG allows the generation of multiple rhythmic breathing patterns and adaptive switching between them, depending on physiological or pathophysiological conditions. These insights open the possibility for site- and mechanism-specific interventions to treat various disorders of the neural control of breathing. ? 2012.
机译:哺乳动物的呼吸运动是由在具有呼吸中心模式发生器(CPG)的空间和功能组织的脑干神经回路中产生的节律性神经活动驱动的。这种有节奏的活动可对血液和组织中的气体进行体内平衡调节,并将呼吸与其他运动行为结合在一起。我们从最近的多学科实验和计算研究中回顾了对该CPG关键神经微电路的空间功能组织的新见解。新兴的观点是,CPG内的微电路组织可根据生理或病理生理状况,生成多种有节奏的呼吸模式并在它们之间进行自适应切换。这些见解为治疗特定部位和机制的干预措施以治疗呼吸神经控制的各种疾病提供了可能性。 ? 2012。

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