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首页> 外文期刊>Trends in Neurosciences >The elusive engram: What can infantile amnesia tell us about memory?
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The elusive engram: What can infantile amnesia tell us about memory?

机译:难以捉摸的枚举:婴儿遗忘症能告诉我们关于记忆的什么信息?

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摘要

Revealing the engram is one of the greatest challenges in neuroscience. Many researchers focus on understanding the cellular and molecular mechanisms underlying the formation and maintenance of the engram, but an underutilized approach has been to investigate analogous processes associated with forgetting. Infant rodents present an ideal model for this purpose because they display a rapid form of non-pathological forgetting known as infantile amnesia (IA). Despite the widespread importance of this interesting phenomenon, the study of the neural bases of IA has remained largely neglected. Here, we consider what IA can tell us about memory. We argue that to understand the mechanisms underlying the engram we must also gain an appreciation of the mechanisms that drive forgetting.
机译:揭露印记是神经科学领域的最大挑战之一。许多研究人员专注于理解形成和维持印记的细胞和分子机制,但未充分利用的方法一直是研究与遗忘有关的类似过程。婴儿啮齿动物为此目的提供了理想的模型,因为它们表现出一种快速的非病理性遗忘形式,即婴儿遗忘症(IA)。尽管这一有趣现象的广泛重要性,但对IA的神经基础的研究仍被很大程度上忽略。在这里,我们考虑IA可以告诉我们有关内存的信息。我们认为,要理解印记的基本机制,我们还必须对驱动遗忘的机制有所了解。

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