...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Trends in Neurosciences >Neurulation: coming to closure.
【24h】

Neurulation: coming to closure.

机译：中和：即将关闭。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neurulation is a morphogenetic event par excellence. During this highly choreographed four-dimensional process, a flat sheet of ectoderm is transformed into an elongated tubular rudiment, the neural tube, which exhibits rostro-caudal and mediolateral regionalization. Many tissues interact during neurulation to induce and regionalize the neuroectoderm and to produce the morphogenetic forces that drive neurulation. Such forces are generated by fundamental cell behaviors such as changes in cell shape, position and number. In addition, morphoregulatory molecules expressed during neurulation underlie induction and patterning of the forming neuraxis. Despite recent advances in our understanding of neurulation, neural tube defects continue to be a major health care concern. Further research, utilizing a panoply of approaches, is necessary to resolve this issue. Thus, although we are beginning to come to closure in terms of understanding the cellular and molecular mechanisms responsible for normal neural tube formation, ?coming to closure' is exactly the problem that requires resolution to prevent these devastating birth defects.
机译：中和是卓越的形态发生事件。在这个高度编排的四维过程中，外胚层的平板被转变成细长的管状残基，即神经管，表现出弓形尾和中外侧区域。在神经形成过程中，许多组织相互作用以诱导神经外胚层并使神经外胚层区域化，并产生驱动神经形成的形态发生力。这种力是由基本的细胞行为产生的，例如细胞形状，位置和数量的变化。另外，在神经期间表达的形态调节分子是形成神经轴的诱导和模式化基础。尽管最近我们对神经的理解有了进步，但神经管缺陷仍然是主要的医疗保健问题。为了解决此问题，有必要使用大量方法进行进一步的研究。因此，尽管我们开始从了解负责正常神经管形成的细胞和分子机制的角度来探讨封闭，但是“封闭”正是需要解决以防止这些破坏性出生缺陷的问题。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号