Endogenous morphine.

Stefano GB; Goumon Y; Casares F; Cadet P; Fricchione GL; Rialas C; Peter D; Sonetti D; Guarna M; Welters ID; Bianchi E

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Endogenous morphine.

机译：内源性吗啡。

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It is now well accepted that endogenous morphine is present in animals, both in invertebrates and vertebrates. It is a key signaling molecule that plays an important role in downregulating physiological responses, such as those in the immune system, including immune elements in the CNS. It has been demonstrated that a specific mu-opiate-receptor subtype, mu3, mediates these downregulatory effects through release of NO. This article examines morphine as an endogenous signaling molecule, in terms of its role in neural and immune regulation.

机译：现在已经公认，无脊椎动物和脊椎动物中均存在内源性吗啡。它是关键的信号分子，在下调生理反应（例如免疫系统中的生理反应，包括中枢神经系统中的免疫元件）中起重要作用。已经证明，一种特定的阿片剂受体亚型mu3通过释放NO介导了这些下调作用。本文就吗啡在神经和免疫调节中的作用进行了研究，认为吗啡是一种内源性信号分子。

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来源
《Trends in Neurosciences》 |2000年第9期|共7页
作者
Stefano GB; Goumon Y; Casares F; Cadet P; Fricchione GL; Rialas C; Peter D; Sonetti D; Guarna M; Welters ID; Bianchi E;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Brain Chemistry; Morphine; Opioid Peptides; Receptors; Opioid; 脑化学; 吗啡; 阿片样肽类; 受体; 阿片样;

机译：Brain Chemistry;Morphine;Opioid Peptides;Receptors;Opioid;脑化学;吗啡;阿片样肽类;受体;阿片样;

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1. Evidence for a role of endogenous neurotensin in the development of sensitization to the locomotor stimulant effect of morphine. [J] . Levesque K, Lamarche C, Rompre PP European Journal of Pharmacology: An International Journal . 2008,第1a3期

机译：内源性神经降压素对吗啡运动刺激作用致敏作用的证据。
2. Assessment of endogenous enkephalins efficacy in the hot plate test in mice: comparative study with morphine. [J] . Noble F, Roques BP Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 1995,第2期

机译：在小鼠热板试验中评估内源性脑啡肽的功效：与吗啡的对比研究。
3. The Quality of Recovery after Dexamethasone, Ondansetron, or Placebo Administration in Patients Undergoing Lower Limbs Orthopedic Surgery under Spinal Anesthesia Using Intrathecal Morphine. A Randomized Controlled Trial [J] . Eduardo Toshiyuki Moro, Miguel Ant?nio Teixeira Ferreira, Renyer dos Santos Gon?alves, Anesthesiology research and practice . 2020,第1期

机译：使用鞘内对吗啡在脊椎麻醉下患者下肢体骨科手术的患者中，ondansetron或安慰剂给药后的恢复质量。随机对照试验
4. Spectral and lifetime measurements of the endogenous fluorescence variation of freshly resected human samples over time: Measuring endogenous fluorescence changes at different moment after tumor or epileptic cortex excision [C] . M. Zanello, A. Ibrahim, F. Poulon, International Conference on Photonics, Optics and Laser Technology . 2016

机译：随时间变化的新鲜切除人类样品的内源性荧光变化的光谱和寿命测量：测量肿瘤或癫痫皮层切除后不同时刻的内源性荧光变化
5. Mechanism design with endogenous information acquisition, endogenous status and endogenous quantities [D] . Shi, Xianwen 2007

机译：具有内生信息获取，内生状态和内生数量的机制设计
6. Alterations in nociception and body temperature after intracisternal administration of neurotensin beta-endorphin other endogenous peptides and morphine. [O] . C B Nemeroff, A J Osbahr 3rd, P J Manberg, 1979

机译：颅内给药神经降压素β-内啡肽其他内源肽和吗啡后痛觉和体温的变化。
7. Endogenous cholinergic neurotransmission contributes to behavioral sensitization to morphine. [O] . Dusica Bajic, Mariano Soiza-Reilly, Allegra L Spalding, 2015

机译：内源性胆碱能神经传递有助于对吗啡的行为致敏。
8. Naloxazone Pretreatment Modifies Cardiorespiratory, Temperature, and Behavioral Effects of Morphine. [R] . Holaday, J. W., Pasternak, G. W., Faden, A. I. 1983

机译：纳洛沙酮预处理可改变吗啡的心肺，温度和行为效应。

Endogenous morphine.

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