Do active cerebral neurons really use lactate rather than glucose?

Chih C; Lipton P; Roberts EL

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Do active cerebral neurons really use lactate rather than glucose?

机译：活跃的大脑神经元真的使用乳酸而不是葡萄糖吗？

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Glucose has long been considered the substrate for neuronal energy metabolism in the brain. Recently, an alternative explanation of energy metabolism in the active brain, the astrocyte-neuron lactate shuttle hypothesis, has received attention. It suggests that during neural activity energy needs in glia are met by anaerobic glycolysis, whereas neuronal metabolism is fueled by lactate released from glia. In this article, we critically examine the evidence supporting this hypothesis and explain, from the perspective of enzyme kinetics and substrate availability, why neurons probably use ambient glucose, and not glial-derived lactate, as the major substrate during activity.

机译：长期以来，葡萄糖一直被认为是大脑神经元能量代谢的基础。最近，活跃的大脑中能量代谢的另一种解释，即星形胶质细胞-神经元乳酸穿梭假说已受到关注。这表明在神经活动期间，厌氧糖酵解可满足神经胶质的能量需求，而神经元的新陈代谢则由神经胶质释放的乳酸推动。在本文中，我们严格审查支持这一假设的证据，并从酶动力学和底物可用性的角度解释为什么神经元可能在活动过程中使用环境葡萄糖而不是胶质细胞来源的乳酸作为主要底物。

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《Trends in Neurosciences》 |2001年第10期|共6页
作者
Chih C; Lipton P; Roberts EL;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Active; Neurons; Lactates; Glucose; 神经元; 乳酸盐类; 葡萄糖;

机译：Active;Neurons;Lactates;Glucose;神经元;乳酸盐类;葡萄糖;

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1. Do active cerebral neurons really use lactate rather than glucose? [J] . Chih C, Lipton P, Roberts EL Trends in Neurosciences . 2001,第10期

机译：活跃的大脑神经元真的使用乳酸而不是葡萄糖吗？
2. Studies on the effects of lactate transport inhibition, pyruvate, glucose and glutamine on amino acid, lactate and glucose release from the ischemic rat cerebral cortex. [J] . Phillis JW, Ren J, ORegan MH Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2001,第1期

机译：研究乳酸运输抑制，丙酮酸，葡萄糖和谷氨酰胺对缺血性大鼠大脑皮层氨基酸，乳酸和葡萄糖释放的影响。
3. Chronic Ethanol Exposure Disrupts Lactate and Glucose Homeostasis and Induces Dysfunction of the Astrocyte–Neuron Lactate Shuttle in the Brain [J] . Lindberg Daniel, Ho Ada Man Choi, Peyton Lee, Alcoholism: Clinical and experimental research . 2019,第9期

机译：慢性乙醇暴露破坏乳酸和葡萄糖稳态，并诱导大脑中的星形胶质细胞 - 神经元乳酸乳酸的功能障碍
4. MRI and PET Study of Cerebral Glucose Metabolism and Its Association with Perihematomal Edema Formation After Intracerebral Hemorrhage in Cats [C] . WANG Jin, rnYANG Jing, rnYU Xiao-xia, The 1st International Symposium on Sectional and Imaging Anatomy . 2007

机译：猫脑出血后脑葡萄糖代谢的MRI和PET研究及其与血肿周围水肿形成的关系
5. Implantable amperometric glucose/lactate sensors with nitric oxide release/generation coatings for enhanced biocompatibility and needle-type glucose sensor for tear glucose measurements [D] . Yan, Qinyi 2011

机译：具有一氧化氮释放/生成涂层的可植入安培型葡萄糖/乳酸盐传感器，可增强生物相容性；针型葡萄糖传感器，用于泪液葡萄糖测量
6. Enzyme Studies in Cerebral Tumours. Lactate Dehydrogenase Glucose Phosphate Isomerase Acid and Alkaline Phosphatase in Plasma Ventricular Cerebrospinal Fluid and Tumour Cyst Fluid from Cases of Glioma and Cerebral Secondary Carcinoma [O] . Monamy Buckell, May C. Robertson 1965

机译：脑肿瘤中的酶研究。胶质瘤和脑继发性癌患者血浆心室脑脊液和肿瘤囊液中的乳酸脱氢酶葡萄糖磷酸异构酶酸和碱性磷酸酶
7. Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo [O] . Itoh, Yoshiaki, Esaki, Takanori, Shimoji, Kazuaki, 2003

机译：二氯乙酸盐对神经元和星形胶质细胞体外葡萄糖和乳酸氧化的影响以及体内脑对葡萄糖利用的影响
8. Measurement of Regional Cerebral Metabolic Rate for Glucose in the Human Subject with (F-18)-2-Deoxy-2-Fluoro-D-Glucose and Emission Computed Tomography: Validation of the Method [R] . Phelps, M. E., Huang, S. C., Hoffman, E. J., 1977

机译：用（F-18）-2-脱氧-2-氟-D-葡萄糖和发射计算机断层扫描测量人类受试者葡萄糖的区域脑代谢率：方法的验证

Do active cerebral neurons really use lactate rather than glucose?

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