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首页> 外文期刊>Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides >A study on Astragalus mongholicus heterosaccharides affecting contractions of isolated bladder detrusor strips
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A study on Astragalus mongholicus heterosaccharides affecting contractions of isolated bladder detrusor strips

机译：黄芪多糖对膀胱逼尿肌条收缩的影响

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摘要

The aim of this study was to examine the effect of Astragalus mongholicus heterosaccharides (AMH) on urinary system. The results of gas chromatography (GC) quantitative analysis of the acetylated of monosaccharides revealed that galactose, arabinose and glucose were the sugars in A mongholicus heterosaccharides. The Fourier transform infrared (FT-1R) spectra indicated that the band in the region of 3258 cm~(-1) is due to the hydroxyl stretching vibration of the polysaccharide. The band in the region of 2927 cm~(-1) is due to C-H stretching vibration. A mongholicus heterosaccharides administration resulted in reduced lipid peroxidation products and increased antioxidant enzyme activities in medicine-treated mice's kidney and urinary bladders. Furthermore, A mongholicus heterosaccharides administration significantly increased mean contractile amplitude increase, contractile frequency and contractile tension in isolated bladder detrusor strips in medicine-treated mice. From these results, it was demonstrated that A mongholicus heterosaccharides have the ability to protect against oxidative damage and improve urinary bladders function. We suppose that A mongholicus heterosaccharides improve urinary bladder function partly through enhancing antioxidant status in kidney and urinary bladders.
机译：这项研究的目的是检查黄芪多糖（AMH）对泌尿系统的影响。气相色谱（GC）定量分析单糖乙酰化的结果表明，半乳糖，阿拉伯糖和葡萄糖是蒙古扁桃多糖中的糖。傅立叶变换红外光谱（FT-1R）表明3258 cm〜（-1）范围内的能带是多糖的羟基拉伸振动所致。 2927 cm〜（-1）范围内的谱带归因于C-H拉伸振动。在药物治疗的小鼠的肾脏和膀胱中，施用Mongholicus杂多糖可减少脂质过氧化产物并增加抗氧化酶活性。此外，在药物治疗的小鼠中，在分离出的膀胱逼尿肌条中，施用Mongholicus杂多糖显着增加了平均收缩幅度的增加，收缩频率和收缩张力。从这些结果证明，蒙古扁桃多糖具有保护免受氧化损伤和改善膀胱功能的能力。我们认为，Mongholicus多糖部分通过增强肾脏和膀胱中的抗氧化剂状态来改善膀胱功能。

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