Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients.

Rowshani AT; Bemelman FJ; van Leeuwen EM; van Lier RA; ten Berge IJ

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Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients.

机译：实体器官移植受者巨细胞病毒感染的临床和免疫学方面。

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Primary cytomegalovirus (CMV) infection is a major cause of morbidity and mortality in recipients after solid organ transplantation (SOT). Widespread and prolonged use of antiviral drugs has changed the natural course of CMV disease by delaying its onset and causing drug resistance. CMV induces a strong cellular immune response, even in immunosuppressed patients, and has developed strategies to evade this immune surveillance. This review summarizes challenges in managing CMV infection in transplant recipients and highlights current insights in the cellular immune response against CMV.

机译：实体器官移植（SOT）后，原发性巨细胞病毒（CMV）感染是受体发病和死亡的主要原因。抗病毒药的广泛和长期使用通过延缓其发作并引起耐药性，改变了CMV疾病的自然病程。即使在免疫抑制的患者中，CMV也会诱导强烈的细胞免疫反应，并已开发出规避这种免疫监视的策略。这篇综述总结了在移植受体中管理CMV感染的挑战，并着重介绍了针对CMV的细胞免疫反应的最新见解。

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《Transplantation: Official Journal of the Transplantation Society》 |2005年第4期|共6页
作者
Rowshani AT; Bemelman FJ; van Leeuwen EM; van Lier RA; ten Berge IJ;
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正文语种 eng
中图分类外科学;
关键词
cisplatin/methotrexate/vinblastine; Solid; Cytomegalovirus Infections; Effects of organ transplant; 巨细胞病毒感染;

机译：cisplatin/methotrexate/vinblastine;Solid;Cytomegalovirus Infections;Effects of organ transplant;巨细胞病毒感染;

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1. Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients. [J] . Rowshani AT, Bemelman FJ, van Leeuwen EM, Transplantation: Official Journal of the Transplantation Society . 2005,第4期

机译：实体器官移植受者巨细胞病毒感染的临床和免疫学方面。
2. Update on cytomegalovirus infections of the gastrointestinal system in solid organ transplant recipients. [J] . Tracy L Lemonovich, Richard R Watkins Current infectious disease reports. . 2012,第1期

机译：实体器官移植受者胃肠系统巨细胞病毒感染的最新进展。
3. Relapsing cytomegalovirus infection in solid organ transplant recipients. [J] . Shanahan A, Malani PN, Kaul DR Transplant infectious disease: an official journal of the Transplantation Society . 2009,第6期

机译：实体器官移植受者中复发性巨细胞病毒感染。
4. Prevalence and Clinical Spectrum of Cytomegalovirus Infection in Newborns and Infants [C] . CM. Mihai, R. Stoicescu, L. Mihai, European Congress of Perinatal Medicine . 2008

机译：新生儿和婴幼儿患有缩细胞病毒感染的患病率与临床谱
5. The Clinical and Economic Burden of Infections in Hospitalized Solid Organ Transplant Recipients in Canada [D] . Hamandi, Bassem. 2020

机译：加拿大住院固体器官移植受者感染的临床和经济负担
6. Comparison of PCR and pp65 antigenemia assay with quantitative shell vial culture for detection of cytomegalovirus in blood leukocytes from solid-organ transplant recipients. [O] . G A Storch, R S Buller, T C Bailey, 1994

机译：PCR和pp65抗原血症检测与定量壳管培养的比较用于检测来自固体器官移植受者的血液白细胞中的巨细胞病毒。
7. Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients [O] . Rowshani Ajda T., Bemelman Frederike J., van Leeuwen Ester M. M., 2005

机译：实体器官移植受者巨细胞病毒感染的临床和免疫学方面

Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients.

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