• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Trends in Neurosciences >Abnormal regulation of corticopetal cholinergic neurons and impaired information processing in neuropsychiatric disorders.
【24h】

Abnormal regulation of corticopetal cholinergic neurons and impaired information processing in neuropsychiatric disorders.

机译：皮质类神经元胆碱能神经元的异常调节和信息处理受损。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cholinergic neurons originating in the basal forebrain innervate all cortical areas and participate in the gating of cortical information processing. Aberrations in the excitability of cortical cholinergic inputs fundamentally alter the processing of sensory stimuli and higher processes, thereby advancing the development of major neuropsychiatric disorders. Cortical cholinergic deafferentation has been considered to be a major neuropathological variable that contributes to the development of age- and dementia-associated impairments in cognition. Conversely, it has been suggested that increases in the excitability of cortical cholinergic inputs mediate the abnormal cognitive processes that escalate into psychotic symptoms and contribute to addictive-drug-seeking behavior, anxiety and phobia. Abnormal regulation of the excitability of cortical cholinergic afferents represents a 'final common pathway' that mediates the manifestation of major neuropsychiatric disorders.
机译：起源于基底前脑的胆碱能神经元支配所有皮质区域，并参与皮质信息处理的门控。皮质胆碱能输入的兴奋性畸变从根本上改变了感觉刺激和更高过程的处理，从而促进了主要的神经精神疾病的发展。皮层胆碱能脱除咖啡因被认为是主要的神经病理学变量，其促进了与年龄和痴呆相关的认知障碍的发展。相反，已经提出，皮质胆碱能输入的兴奋性增加介导了异常的认知过程，该异常的认知过程逐渐升级为精神病性症状并导致成瘾的寻求药物行为，焦虑和恐惧症。皮质胆碱能传入神经兴奋性的异常调节代表了介导主要神经精神疾病表现的“最终共同途径”。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号