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首页> 外文期刊>Transplantation: Official Journal of the Transplantation Society >Complement fragment C4d deposition in peritubular capillaries in acute humoral rejection after ABO blood group-incompatible human kidney transplantation.
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Complement fragment C4d deposition in peritubular capillaries in acute humoral rejection after ABO blood group-incompatible human kidney transplantation.

机译：ABO血型不相容的人肾移植后急性体液排斥反应中补体片段C4d在肾小管毛细血管中的沉积。

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摘要

BACKGROUND Acute humoral rejection (AHR) is the most important risk factor for early graft loss in ABO-incompatible (ABO-i) kidney transplantation (RTx). The pathogenesis and diagnostic criteria for AHR after ABO-i RTx remain unclear. Complement fragment C4d deposition in peritubular capillaries (PTC), which is a sensitive indicator for activation of the classical complement pathway, was studied to establish the pathologic diagnostic indicator of AHR.METHODS Forty-four graft biopsy specimens from 19 patients with ABO-i living donors were analyzed within 90 days after RTx. Nineteen biopsy specimens with acute rejection after ABO-compatible (ABO-c) living-related RTx were used as controls. Diffuse and bright C4d deposition in PTC was considered significantly positive.RESULTS All of 8 recipients with AHR showed significantly positive C4d in PTC in the ABO-i group, but 9 of 11 recipients without AHR were negative. In the ABO-c RTx group, 16 of 19 recipients were negative for C4d in PTC. The prevalence of C4d in PTC was significantly higher in ABO-i RTx ( <0.05).CONCLUSIONS C4d deposition is valuable as a specific and sensitive indicator for AHR, even of mild severity, in ABO-i RTx.
机译：背景技术急性体液排斥（AHR）是ABO不相容（ABO-i）肾移植（RTx）中早期移植物丢失的最重要危险因素。 ABO-i RTx后AHR的发病机理和诊断标准尚不清楚。研究了补体片段C4d在肾小管毛细血管（PTC）中的沉积，这是激活经典补体途径的敏感指标，旨在建立AHR的病理诊断指标。方法：对19例ABO-i活患者的44例活检标本进行了研究。 RTx后90天内分析供体。十九个活检标本在与ABO相容（ABO-c）生活相关的RTx后出现急性排斥反应，被用作对照。结果PTC中弥漫性和明亮的C4d沉积被认为是显着阳性。结果ABO-i组的8名AHR接受者在PTC中均显着C4d阳性，但是11名无AHR的接受者中有9例为阴性。在ABO-c RTx组中，在19位接受者中，有16位在PTC中C4d阴性。结论在ABO-i RTx中PTC中C4d的患病率显着较高（<0.05）。

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