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首页> 外文期刊>Value in health: the journal of the International Society for Pharmacoeconomics and Outcomes Research >Comparison of EQ-5D scores among anthracycline-containing regimens followed by taxane and taxane-only regimens for node-positive breast cancer patients after surgery: The N-SAS BC 02 trial
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Comparison of EQ-5D scores among anthracycline-containing regimens followed by taxane and taxane-only regimens for node-positive breast cancer patients after surgery: The N-SAS BC 02 trial

机译：N-SAS BC 02试验对淋巴结阳性乳腺癌患者术后采用含蒽环类药物的方案后采用紫杉类和仅使用紫杉类方案的EQ-5D评分的比较

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Objective: To examine health-related quality of life, we investigated the effect of adjuvant chemotherapy regimens on utility scores assessed by the EuroQoL-5D (EQ-5D) instrument in a randomized, controlled trial for breast cancer patients after surgery. We also investigated the relationship between Functional Assessment of Cancer Therapy (FACT) scale scores and EQ-5D utilities. Methods: Patients were randomly assigned to the following four chemotherapy regimens: four cycles of anthracycline followed by paclitaxel (ACP), four cycles of anthracycline-containing regimens followed by docetaxel (ACD), eight cycles of paclitaxel (PTX), and eight cycles of docetaxel (DTX). Of 1060 registered, the first 300 consecutive patients were included in the current utility study. Utility scores were assessed using the EQ-5D instrument at baseline; cycles 3, 5, and 7; 7 months; and 1 year. We also evaluated the correlation between these scores and FACT-G, -B, and -Taxane scores at each time point. Results: Utility scores were significantly lower in the DTX group than in the ACP and ACD groups. Mean utility scores in the DTX group were lowest at 7 months and tended to remain low for a long time. The combined anthracycline followed by taxane group had significantly higher utility scores that the taxane-alone group, with no significant difference depending on the type of taxane. Only the FACT-G social/family well-being subscale had no relationship with EQ-5D responses and utility scores. Conclusions: Although the regimens in this study were similar in that they included taxane, the mean utility scores and longitudinal patterns of utility scores were different among regimens.
机译：目的：为了检查与健康相关的生活质量，我们在乳腺癌患者术后随机对照试验中，研究了辅助化疗方案对通过EuroQoL-5D（EQ-5D）仪器评估的效用评分的影响。我们还研究了癌症治疗功能评估（FACT）量表评分与EQ-5D效用之间的关系。方法：将患者随机分配至以下四种化疗方案：四个周期的蒽环类药物联合紫杉醇（ACP），四个周期的含蒽环类药物方案联合多西紫杉醇（ACD），八个周期的紫杉醇（PTX）和八个周期的多西他赛（DTX）。在目前登记的效用研究中，已登记​​的1060名患者中，前300名连续患者。在基线时使用EQ-5D仪器评估效用分数;循环3、5和7; 7个月;和1年。我们还评估了每个时间点这些分数与FACT-G，-B和-Taxane分数之间的相关性。结果：DTX组的效用得分显着低于ACP和ACD组。 DTX组的平均效用得分在7个月最低，并且长期保持较低水平。联合使用蒽环类药物和紫杉烷类药物的效用得分明显高于单独使用紫杉烷类药物的得分，但根据紫杉烷类型的不同，差异无统计学意义。只有FACT-G的社交/家庭福祉分量表与EQ-5D的反应和效用得分无关。结论：尽管本研究中的方案相似，包括紫杉烷类方案，但方案之间的平均效用得分和效用得分的纵向模式不同。

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