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首页> 外文期刊>Turkish Journal of Fisheries & Aquatic Sciences >Studies on Induction of Nuclear Abnormalities in Peripheral Blood Erythrocytes of Fish Exposed to Copper
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Studies on Induction of Nuclear Abnormalities in Peripheral Blood Erythrocytes of Fish Exposed to Copper

机译：铜暴露对鱼类外周血红细胞核异常的诱导研究

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摘要

A wide variety of chemicals especially metals contaminate the aquatic ecosystem and stimulate a variety of toxicity mechanisms, such as oxidative damage to proteins, DNA and lipids. Very limited efforts have been made to investigate the genotoxic effects of metals in fish. Therefore, the present study was conducted to determine copper induced genotoxic damage in peripheral blood erythrocytes of 150-day old four freshwater fish species viz. Labeo rohita, Cirrhina mrigala, Catla catla and Ctenopharyngodon idella by using micronucleus test. For this purpose, 96-hr LC50 and lethal concentration of copper for all the four fish species were determined. Each fish species was exposed to four different sub-lethal concentrations (17, 25, 33, 50% of 96-hr LC50) of copper, separately, for a period of 30 days. Results showed exposure concentration dependent increases in the frequencies of micronuclei and other nuclear abnormalities. Findings of the experiment also confirmed that the micronucleus test acts as a useful tool in determining the potential genotoxicity of metals in erythrocytes of various fish species. Among four fish species, Cirrhina mrigala showed significantly higher frequency of micronuclei with the mean value of 16.98 +/- 11.70%, followed by that of Ctenopharyngodon idella, Catla catla and Labeo rohita. However, frequency of other nuclear abnormalities followed the order: Labeo rohita > Cirrhina mrigala > Ctenopharyngodon idella > Catla catla.
机译：各种各样的化学物质（尤其是金属）污染了水生生态系统，并刺激了多种毒性机制，例如对蛋白质，DNA和脂质的氧化性破坏。为研究金属在鱼类中的遗传毒性作用，所做的工作非常有限。因此，本研究旨在确定铜诱导的150日龄四种淡水鱼类物种外周血红细胞的遗传毒性损害。通过使用微核试验，Labeo rohita，Cirrhina mrigala，Catla catla和Ctenopharyngodon idella。为此，确定了所有四种鱼类的96小时LC50和致命铜浓度。每种鱼类分别暴露于四种不同的亚致死浓度（96小时LC50的17％，25％，33％，50％），持续30天。结果表明，暴露浓度依赖于微核和其他核异常频率的增加。实验结果还证实，微核试验可作为确定各种鱼类红细胞中金属潜在遗传毒性的有用工具。在四种鱼类中，Cirrhina mrigala表现出更高的微核频率，平均值为16.98 +/- 11.70％，其次是Ctenopharyngodon idella，Catla catla和Labeo rohita。但是，其他核异常的发生频率遵循以下顺序：Labeo rohita> Cirrhina mrigala> Ctenopharyngodon idella> Catla catla。

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