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Antitumor polysaccharides from mushrooms: a review on the structural characteristics, antitumor mechanisms and immunomodulating activities

机译：蘑菇的抗肿瘤多糖：结构特征，抗肿瘤机制和免疫调节活性的综述。

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摘要

Mushrooms are popular folk medicines that have attracted considerable attention because of their efficient antitumor activities. This review covers existing research achievements on the mechanisms of isolated mushroom polysaccharides, particularly (1 -> 3)-beta-D-glucans. Our review also describes the function in modulating the immune system and potential tumor-inhibitory effects of polysaccharides. The antitumor mechanisms of mushroom polysaccharides are mediated by stimulated T cells or other immune cells. These polysaccharides are able to trigger various cellular responses, such as the expression of cytokines and nitric oxide. Most polysaccharides could bind other conjugate molecules, such as polypeptides and proteins, whose conjugation always possess strong antitumor activities. The purpose of this review is to summarize available information, and to reflect the present situation of polysaccharide research filed with a view for future direction. (C) 2016 Elsevier Ltd. All rights reserved.
机译：蘑菇是流行的民间药物，由于其有效的抗肿瘤活性而引起了极大的关注。这篇综述涵盖了有关分离的蘑菇多糖，特别是（1-> 3）-β-D-葡聚糖的机理的现有研究成果。我们的综述还描述了调节免疫系统的功能和多糖的潜在肿瘤抑制作用。蘑菇多糖的抗肿瘤机制是由刺激的T细胞或其他免疫细胞介导的。这些多糖能够触发各种细胞反应，例如细胞因子和一氧化氮的表达。大多数多糖可以结合其他结合分子，例如多肽和蛋白质，它们的结合始终具有很强的抗肿瘤活性。这篇综述的目的是总结可用的信息，并反映多糖研究的现状，以期未来发展方向。 （C）2016 Elsevier Ltd.保留所有权利。

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