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首页> 外文期刊>Veterinary and Comparative Oncology >Oligodendroglial Gliomatosis cerebri in a Poodle.
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Oligodendroglial Gliomatosis cerebri in a Poodle.

机译：贵宾犬中的少突胶质 Gliomatosis cerebri 。

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摘要

Gliomatosis cerebri (GC) is a rare, diffusely infiltrating, glial cell tumour of neuroepithelial origin. This report describes a case of oligodendroglial GC in a 6-year-old male Poodle with central nervous system symptoms. Computed tomography revealed anomalous parenchyma density and ventricular asymmetry. Cerebrospinal fluid showed elevated protein (30 mg dL-1) and nucleated cell count (20 micro L-1). Presumptive diagnosis of necrotizing meningoencephalitis was made. Because of rapid deterioration of the general condition of the animal, the dog was euthanized. Histologically there was an infiltration of round or ovoid neoplastic cells in the white matter of the left cerebral hemisphere and in leptomeninges. Immunohistochemistry showed that 80% of the neoplastic cells expressed Olig2 and some 50% expressed glial fibrilary acidic protein. On the basis of clinical, histological and immunohistochemical features, a diagnosis of oligodendoglial GC was done. This case represents the first report of a case of oligodendroglial GC in the canid.Digital Object Identifier http://dx.doi.org/10.1111/j.1476-5829.2010.00219.x
机译：脑胶质瘤（GC）是一种罕见的，弥漫性浸润的神经上皮起源的神经胶质细胞瘤。该报告描述了一例中枢神经系统症状的6岁男性贵宾犬少突胶质GC。计算机体层摄影术显示异常实质密度和心室不对称。脑脊液显示蛋白质升高（30 mg dL -1 ）和有核细胞计数（20 micro L -1 ）。做出坏死性脑膜脑炎的推定诊断。由于动物一般状况的迅速恶化，对狗实施了安乐死。组织学上，在左脑半球的白质和软脑膜中有圆形或卵圆形的肿瘤细胞浸润。免疫组织化学显示，80％的肿瘤细胞表达Olig2，约50％的细胞表达神经胶质纤维酸性蛋白。根据临床，组织学和免疫组化特征，诊断为少突牙弓GC。此案例代表犬科中少突胶质GC案例的首次报告。数字对象标识符http://dx.doi.org/10.1111/j.1476-5829.2010.00219.x

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