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首页> 外文期刊>Veterinary and Comparative Oncology >Insulin receptor is expressed in normal canine mammary gland and benign adenomas but decreased in metastatic canine mammary carcinomas similar to human breast cancer.
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Insulin receptor is expressed in normal canine mammary gland and benign adenomas but decreased in metastatic canine mammary carcinomas similar to human breast cancer.

机译：胰岛素受体在正常犬乳腺和良性腺瘤中表达，但在与人乳腺癌相似的转移性犬乳癌中表达减少。

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摘要

Insulin receptor (INSR) or insulin-like growth factor (IGF) signalling is speculated to be involved in mammary tumour development. Expression levels of members of the insulin receptor family (INSR, IGF1R, IGF2R, GHR) and their ligands IGF1and IGF2 were quantified in macro- and microdissected tissue samples of normal canine mammary gland, adenomas, carcinomas and their lymph node metastases to evaluate their potential impact on the carcinogenesis of canine mammary tumours. Normal mammary gland and adenomas had strong INSR expression, while carcinomas and metastases had significantly decreased expression. No differences were observed for IGF1R expression. IGF1, IGF2 and GHR mRNA expressions were strongly decreased in adenomas, carcinomas and metastases. INSR and IGF1R are therefore expressed in normal gland and adenomas and an increased stimulus by their ligands may be a proliferative stimulus in those tissues. However, decreased INSR expression carcinomas and their metastases render questionable its impact at late stages of carcinogenesis.
机译：胰岛素受体（INSR）或胰岛素样生长因子（IGF）信号被推测与乳腺肿瘤的发展有关。在正常犬乳腺，腺瘤，癌及其淋巴结转移的宏观和微观解剖组织样品中，对胰岛素受体家族成员（INSR，IGF1R，IGF2R，GHR）及其配体IGF1和IGF2的表达水平进行定量分析，以评估其潜力对犬乳腺肿瘤致癌作用的影响。正常的乳腺和腺瘤具有很强的INSR表达，而癌和转移瘤的表达明显降低。没有观察到IGF1R表达的差异。在腺瘤，癌和转移瘤中，IGF1，IGF2和GHR mRNA表达大大降低。因此，INSR和IGF1R在正常的腺体和腺瘤中表达，通过它们的配体增加的刺激可能是那些组织中的增殖刺激。然而，减少的INSR表达癌及其转移使其在致癌晚期的影响值得怀疑。

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