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首页> 外文期刊>Veterinary and Comparative Oncology >Mast cells in canine mammary gland tumour: number, distribution and EPOR positivity.
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Mast cells in canine mammary gland tumour: number, distribution and EPOR positivity.

机译：犬乳腺肿瘤中的肥大细胞：数量，分布和EPOR阳性。

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摘要

Erythropoietin (EPO)-mediated mitogenic and anti-apoptotic effects involve all the cells expressing functional receptors for EPO (EPOR), as demonstrated by in vitro and in vivo studies. EPO shows pleiotropic effects and acts as an endogenous mediator of adaptive tissue response to metabolic stress protecting tissues from different injuries. Recently, the EPO/EPOR complex has been identified in several neoplastic cell lines and solid tumours. In this study, the authors investigated the mast cells (MCs) number, distribution and their immunoreactivity for EPOR in normal, dysplastic and neoplastic canine mammary gland. The results showed that MCs were more numerous in displastic glands compared with normal and neoplastic glands. As far as the EPOR immunoreactivity is concerned, we did not observe MCs reaction on cancer, in contrast with previously published data where epithelium of neoplastic gland showed an increase in EPOR expression along with the neoplastic progression. Overall, our results might be suggestive for MCs role in oncogenesis and offer new insight regarding to the expression of EPOR in mammary gland cancer in dog.
机译：促红细胞生成素（EPO）介导的促有丝分裂和抗凋亡作用涉及所有表达EPO（EPOR）功能受体的细胞，如体外和体内研究所示。 EPO表现出多效作用，并充当适应性组织响应代谢应激的内源性介质，从而保护组织免受不同伤害。最近，已经在几种肿瘤细胞系和实体瘤中发现了EPO / EPOR复合物。在这项研究中，作者研究了正常，发育不良和赘生犬乳腺中肥大细胞（MCs）的数量，分布及其对EPOR的免疫反应性。结果表明，与正常腺瘤和赘生性腺相比，增生腺中的MC数量更多。就EPOR免疫反应性而言，我们没有观察到MC对癌症的反应，这与以前发表的数据相反，在先前发表的数据中，肿瘤腺上皮显示EPOR表达随肿瘤进展而增加。总体而言，我们的结果可能暗示MC在肿瘤发生中的作用，并为EPOR在犬乳腺癌中的表达提供新的见解。

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