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首页> 外文期刊>Veterinary and Comparative Oncology >Induction of VEGF by tepoxalin does not lead to increased tumour growth in a canine osteosarcoma xenograft.
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Induction of VEGF by tepoxalin does not lead to increased tumour growth in a canine osteosarcoma xenograft.

机译：Tepoxalin诱导VEGF不会导致犬骨肉瘤异种移植物中肿瘤生长的增加。

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摘要

The purpose of this study was to determine the impact of the non-steroidal anti-inflammatory drug tepoxalin on canine tumour cell growth and describe the changes associated with tepoxalin treatment. In vitro experiments were performed to assess tepoxalin-associated alterations in tumour cell growth. Clinically achievable tepoxalin concentrations did not significantly alter tumour cell growth in vitro. Vascular endothelial growth factor (VEGF) production and hypoxia-inducible factor-1alpha dose-dependently increased in vitro in the presence of tepoxalin. A canine osteosarcoma xenograft was used to determine in vivo effects of tepoxalin on tumour growth and angiogenesis. Despite increased VEGF in vitro, there was a significant growth delay associated with tepoxalin treatment. Normal dogs were administered tepoxalin to assess effects on systemic VEGF production, but not found to have significantly increased VEGF. These data suggest that tepoxalin may moderately inhibit tumour growth and may be administered as an analgesic to tumour-bearing dogs. Copyright 2010 Blackwell Publishing Ltd.
机译：这项研究的目的是确定非甾体抗炎药替泊沙林对犬肿瘤细胞生长的影响，并描述与替泊沙林治疗相关的变化。进行了体外实验以评估替泊沙林相关肿瘤细胞生长的变化。临床上可达到的替泊沙林浓度没有显着改变体外肿瘤细胞的生长。在替泊沙林的存在下，血管内皮生长因子（VEGF）的产生和缺氧诱导因子-1α剂量依赖性地增加。犬骨肉瘤异种移植物用于确定替泊沙林对肿瘤生长和血管生成的体内作用。尽管体外VEGF增加，但是与替泊沙林治疗相关的显着生长延迟。正常犬服用替泊沙林以评估其对全身VEGF产生的影响，但未发现VEGF显着增加。这些数据表明替泊沙林可以适度地抑制肿瘤的生长，并且可以作为荷瘤犬的止痛剂。版权所有2010 Blackwell Publishing Ltd.

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