• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Veterinary and Comparative Oncology >Inductively coupled plasma mass-spectrometric determination of platinum in excretion products of client-owned pet dogs
【24h】

Inductively coupled plasma mass-spectrometric determination of platinum in excretion products of client-owned pet dogs

机译：自有宠物狗排泄物中的电感耦合等离子体质谱法测定铂

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Residues of antineoplastic drugs in canine excretion products may represent exposure risks to veterinary personnel, owners of pet dogs and other animal care-takers. The aim of this study was to measure the extent and duration of platinum (Pt) excretion in pet dogs treated with carboplatin. Samples were collected before and up to 21 days after administration of carboplatin. We used validated, ultra-sensitive, inductively coupled plasma-mass spectrometry assays to measure Pt in canine urine, faeces, saliva, sebum and cerumen. Results showed that urine is the major route of elimination of Pt in dogs. In addition, excretion occurs via faeces and saliva, with the highest amounts eliminated during the first 5 days. The amount of excreted Pt decreased over time but was still quantifiable at 21 days after administration of carboplatin. In conclusion, increased Pt levels were found in all measured excretion products up to 21 days after administration of carboplatin to pet dogs, with urine as the main route of excretion. These findings may be used to further adapt current veterinary guidelines on safe handling of antineoplastic drugs and treated animals.
机译：犬类排泄产品中抗肿瘤药的残留可能对兽医人员，爱犬的主人和其他动物照料者造成接触风险。这项研究的目的是测量用卡铂治疗的宠物狗中铂（Pt）排泄的程度和持续时间。在施用卡铂之前和之后直至21天收集样品。我们使用经过验证的超灵敏电感耦合等离子体质谱法测定犬尿，粪便，唾液，皮脂和子宫中的铂。结果表明，尿液是消除狗体内Pt的主要途径。另外，排泄物是通过粪便和唾液发生的，在最初的5天中排泄量最大。排泄的Pt量随时间而减少，但在给予卡铂后21天仍可定量。总之，直至对宠物犬施用卡铂后直至21天，所有测得的排泄物中Pt含量均升高，其中尿为主要排泄途径。这些发现可用于进一步适应当前关于安全处理抗肿瘤药和治疗动物的兽医指南。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号