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首页> 外文期刊>Veterinary Immunology and Immunopathology >Host immune-related gene responses against highly pathogenic avian influenza virus infection in vitro differ among chicken cell lines established from different organs.
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Host immune-related gene responses against highly pathogenic avian influenza virus infection in vitro differ among chicken cell lines established from different organs.

机译：在不同器官建立的鸡细胞株之间，针对高致病性禽流感病毒体外感染的宿主免疫相关基因反应不同。

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摘要

Highly pathogenic avian influenza virus (HPAIV) induces acute disease in chickens causing high mortality and morbidity and is a major threat to poultry industries in Southeast Asian countries. The mechanisms of disease manifestation and host innate immune responses against HAPIV in chickens are not well understood. In this study, we examined virus replication and host gene expressions in four chicken cell lines in vitro to elucidate the impact of host innate immune responses against viral replication. It was demonstrated that viral replication efficiencies were different depending on the cell line. The viral replication appeared to be affected by the basal expression of IFN related genes. The expression of immune-related genes against the viral infection also varied in a cell line dependent manner. In non-immune derived cell lines, but not in immune derived cell lines, the expression of the CCL5 and CCL20 genes were induced by HPAIV infection. Reverse genetics HPAIV, with internal genes from avirulent avian influenza, reduced virus replication and affected immune-related gene expression in a cell line dependent manner. These results suggest the possibility that differential immune responses in different cell types in local tissues could modulate the consequences of HPAIV infection in chickens.Digital Object Identifier http://dx.doi.org/10.1016/j.vetimm.2011.10.002
机译：高致病性禽流感病毒（HPAIV）在鸡中诱发急性疾病，导致高死亡率和高发病率，是对东南亚国家家禽业的主要威胁。鸡的疾病表现和宿主针对HAPIV的先天免疫应答的机制尚未完全了解。在这项研究中，我们在体外检查了四种鸡细胞系中的病毒复制和宿主基因表达，以阐明宿主固有的免疫反应对病毒复制的影响。已经证明病毒复制效率根据细胞系而不同。病毒复制似乎受到IFN相关基因基础表达的影响。抵抗病毒感染的免疫相关基因的表达也以细胞系依赖性方式变化。在非免疫衍生细胞系中，而非免疫衍生细胞系中，CCL5和CCL20基因的表达是由HPAIV感染诱导的。反向遗传学HPAIV具有无毒禽流感的内部基因，可减少病毒复制并以细胞系依赖性方式影响免疫相关基因的表达。这些结果表明，局部组织中不同细胞类型的不同免疫反应可能会调节鸡HPAIV感染的后果。数字对象标识符http://dx.doi.org/10.1016/j.vetimm.2011.10.002

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