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首页> 外文期刊>Vascular and endovascular surgery >Electrical stimulation promotes angiogenesis in a rabbit hind-limb ischemia model.
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Electrical stimulation promotes angiogenesis in a rabbit hind-limb ischemia model.

机译：电刺激促进兔后肢缺血模型中的血管生成。

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摘要

In previous investigations, it was shown that applying a modest regimen of electrical stimulation (ES), even in severely ischemic tissue, improves the healing process, accelerates neovascularization, and enhances angiogenesis in muscle tissue. Our objective in this current report was to further understand ES as a potential alternative treatment for severe muscle ischemia. Immediately after the left distal external iliac artery and the femoral artery were excised, ES (30 contractions per minute [cpm], 2 V, single impulses per burst) was applied to rabbit adductor muscle near the site of the excised femoralis artery for 24 hours daily over 1 month. Three other series served as controls: ES without arterial excision; arterial excision without ES or lead implantation; and arterial excision with lead implantation but no ES. Histologic study of capillary density was performed by angiography (employing a grid template) and by measuring the lower limb-calf blood pressure ratio. At the end of 30 days in the ES series, 10.5 +/-1.2 contrast-medium opacified arteries (COAs) crossed a specific grid section segment compared with 7.2 +/-1.5 in the control series without ES (p<0.05); 68.2 +/-9.3 COAs crossed a grid section compared with 43.2 +/-6.4 in controls (p<0.05); 27.3 +/-1.2 grids contained COAs compared with 29.3 +/-3.5 in controls (p<0.05); lower limb-calf blood pressure ratio was 0.81 +/-0.06 compared with 0.31 +/-0.07 in controls (p<0.05); and capillary density was 283.7 +/-24.5 mm2 compared with 91.4 +/-20.9 mm2 in controls (p<0.001). These preliminary results show that cautious ES enhances and accelerates muscle revascularization in severely ischemic tissue.
机译：在以前的研究中，表明即使在严重缺血的组织中也要采用适度的电刺激（ES）方案，可以改善愈合过程，加速新血管形成，并增强肌肉组织中的血管生成。我们在本报告中的目的是进一步了解ES作为重度肌肉缺血的潜在替代疗法。切除左distal外远端动脉和股动脉后，立即将ES（每分钟30次收缩[cpm]，2 V，每次爆发一次脉冲）施加到离断股动脉附近的兔内收肌上24小时每天超过1个月。其他三个系列作为对照：无动脉切除的ES;以及没有ES或铅植入的动脉切除;和铅植入的动脉切除术，但没有ES。毛细血管密度的组织学研究是通过血管造影（采用网格模板）和测量下肢-小腿血压比来进行的。在ES系列的30天结束时，有10.5 +/- 1.2个造影剂的中度不透明动脉（COA）穿过了一个特定的网格部分，而在没有ES的对照系列中，则为7.2 +/- 1.5（p <0.05）; 68.2 +/- 9.3 COA穿过网格截面，而对照组为43.2 +/- 6.4（p <0.05）; 27.3 +/- 1.2网格包含COA，而对照组为29.3 +/- 3.5（p <0.05）;下肢小腿血压比率为0.81 +/- 0.06，而对照组为0.31 +/- 0.07（p <0.05）;毛细血管密度为283.7 +/- 24.5 mm2，而对照组为91.4 +/- 20.9 mm2（p <0.001）。这些初步结果表明，谨慎的ES可以增强并加速严重缺血组织中的肌肉血运重建。

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