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首页> 外文期刊>Vascular and endovascular surgery >Dyslipidemia Part 2: Review of Dyslipidemia Treatment in Patients With Noncoronary Vascular Disease
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Dyslipidemia Part 2: Review of Dyslipidemia Treatment in Patients With Noncoronary Vascular Disease

机译：血脂异常第2部分：非冠状动脉疾病患者血脂异常治疗的回顾

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摘要

Dyslipidemia is one of the major modifiable risk factors associated with atherosclerotic cardiovascular disease. Appropriate modification of lipid profiles reduces the progression of atherosclerosis in vessel walls across all vascular beds. The management of dyslipidemia has evolved over the last several decades, especially since the discovery of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, also known as statins. Statin use in atherosclerotic heart disease is well described in observational and prospective placebo-controlled studies, citing both lipid-lowering and pleiotropic effects. However, the effect of statins and other lipid-lowering agents on noncoronary arterial beds (the aorta, arteries to the extremities, renal, and carotid arteries) is less understood. This article is part 2 of a 2-part review, with part 1 having focused on lipid metabolism and the downstream effects of lipids on the development of atherosclerosis. The current review (part 2) will discuss trials, retrospective reviews, and observational cohort studies regarding the use of statins and/or other lipid-lowering drugs for primary and secondary prevention of peripheral noncoronary atherosclerotic disease.
机译：血脂异常是与动脉粥样硬化性心血管疾病相关的主要可改变危险因素之一。适当调整脂质分布可减少所有血管床中血管壁的动脉粥样硬化进展。在最近的几十年中，血脂异常的管理得到了发展，特别是自发现3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂（也称为他汀类药物）以来。在观察性和前瞻性安慰剂对照研究中，他汀类药物在动脉粥样硬化性心脏病中的使用均得到了很好的描述，并列举了降脂和多效性作用。但是，他汀类药物和其他降血脂药对非冠状动脉床（主动脉，四肢动脉，肾动脉和颈动脉）的作用了解得很少。本文是由两部分组成的综述的第2部分，第1部分着重于脂质代谢以及脂质对动脉粥样硬化发展的下游影响。本篇综述（第2部分）将讨论有关他汀类药物和/或其他降脂药物在外周非冠状动脉粥样硬化疾病一级和二级预防中的应用的试验，回顾性综​​述和观察性队列研究。

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