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首页> 外文期刊>Vascular and endovascular surgery >Platelet activation in bypass surgery for critical limb ischemia.
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Platelet activation in bypass surgery for critical limb ischemia.

机译：危重肢体缺血旁路手术中的血小板活化。

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Platelet activation contributes to graft occlusion after bypass surgery. This study investigated platelet activation status before, during, and after bypass. Blood was taken preoperatively from patients undergoing femoro-popliteal bypass and at incision, after dissection, after ischemia, after reperfusion, 24 hours after surgery, and almost 2 years after bypass (and given aspirin or warfarin). Platelet aggregation was measured using a turbidimetric method and platelet activation with flow cytometry. Statistical analysis was performed using Mann-Whitney U and Wilcoxon's tests. Resting platelet activation was similar between controls and patients undergoing bypass. Platelet activation decreased at incision but remained highly reactive. Platelet aggregation increased after dissection and the ischemic phase but significantly decreased after reperfusion. Platelet aggregation and activation were increased at 24 hours and subsequently after bypass. Platelets in critical limb ischemia exist in the primed stateand become activated by minimum stimuli. Increased platelet activation occurs after bypass grafting for critical limb ischemia despite adjunctive therapy.
机译：旁路手术后血小板活化有助于移植物闭塞。这项研究调查了旁路之前，期间和之后的血小板激活状态。术前从股pop搭桥术中，切开后，缺血后，再灌注后，手术后24小时以及搭桥术后近2年（并给予阿司匹林或华法林）的患者术前采血。使用比浊法测量血小板聚集，并使用流式细胞术测量血小板活化。使用Mann-Whitney U和Wilcoxon的检验进行统计分析。对照组和接受旁路治疗的患者之间的静息血小板活化相似。切口处的血小板活化降低，但仍保持高反应性。解剖和缺血期后血小板聚集增加，但再灌注后血小板聚集明显减少。血小板聚集和激活在24小时及旁路后增加。严重肢体缺血中的血小板以启动状态存在，并通过最少的刺激而被激活。尽管有辅助治疗，但对于严重肢体缺血的旁路移植术后，血小板活化增加。

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