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Serum concentrations of IgG, IgA, and IgM in retired racing Greyhound dogs

机译：退休的赛狗狗的血清IgG，IgA和IgM的浓度

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BackgroundGreyhound dogs have significant physiologic, hematologic, and biochemical differences when compared with other breeds, including significantly lower serum globulin concentration owing to decreases in the alpha- and beta-globulin fractions. The specific proteins that account for differences in globulin concentrations are not known, but IgA and IgM, both beta-globulins, are potential candidates.ObjectivesThe aims of this study were to measure serum IgG, IgA, and IgM in clinically healthy retired racing Greyhounds and compare the results with those of age- and sex-matched non-Greyhound dogs.MethodsStudy animals included 25 Greyhound and 20 non-Greyhound dogs. Total protein, albumin, and total globulin concentrations were determined. IgG, IgA, and IgM concentrations were measured using a commercially available radial immunodiffusion kit. The Student t-test assuming equal variances was used to compare concentrations of immunoglobulins between groups.ResultsSerum concentrations of IgA and IgM in Greyhounds (IgA=49 +/- 20 mg/dL; IgM=132 +/- 47 mg/dL) were significantly lower than concentrations in non-Greyound dogs (IgA=70 +/- 39 mg/dL; Ig M=212 +/- 78 mg/dL). Concentrations of IgG did not differ between groups.ConclusionsMean serum IgA and IgM concentrations in Greyhounds were lower than those in non-Greyhound dogs. This may contribute to low serum concentrations of beta-globulins in Greyhounds. Specific reference intervals are recommended for Greyhounds to avoid possible misdiagnosis of IgA or IgM deficiency.
机译：背景与其他犬种相比，灵缇犬具有明显的生理，血液和生化差异，其中包括由于α和β球蛋白含量降低而导致的血清球蛋白浓度明显降低。尚不清楚引起球蛋白浓度差异的特定蛋白质，但可能都是候选的IgA和IgM（均为β-球蛋白）。方法将研究对象与25只灵狮犬和20只非灵狮犬进行比较。测定总蛋白，白蛋白和总球蛋白浓度。 IgG，IgA和IgM浓度是使用市售的放射免疫扩散试剂盒测量的。使用假设均方差相等的Student t检验比较两组之间的免疫球蛋白浓度。明显低于非灰狗的浓度（IgA = 70 +/- 39 mg / dL; Ig M = 212 +/- 78 mg / dL）。两组间IgG的浓度无差异。结论灵狮犬的平均血清IgA和IgM浓度低于非灵狮犬。这可能会导致灵缇犬的血清β-球蛋白浓度降低。建议为灵狮使用特定的参考间隔，以避免可能的IgA或IgM缺乏症的误诊。

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