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首页> 外文期刊>Veterinary Dermatology >Dose tapering for ciclosporin in cats with nonflea-induced hypersensitivity dermatitis
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Dose tapering for ciclosporin in cats with nonflea-induced hypersensitivity dermatitis

机译：非跳蚤诱发的超敏性皮炎猫的环孢素剂量逐渐减少

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Background - Little information is available on the ciclosporin dose-tapering regimen and clinical response in the treatment of feline hypersensitivity dermatitis. Hypothesis/Objectives - To test a dose-tapering regimen and assess efficacy and clinical safety for up to 18 weeks. Animals - Eighty-eight client-owned cats with feline hypersensitivity dermatitis. Methods - Cats that received either a placebo or ciclosporin at 2.5 mg/kg or 7 mg/kg daily for 6 weeks were given 7 mg/kg ciclosporin daily for 4 weeks. Depending on the clinical response, the dose was tapered from daily to every other day over the next 4 weeks and further to twice a week for an additional 4 weeks. Results - After all cats received 7 mg/kg for 4 weeks, the dose could be tapered to every other day for the next 4 weeks in 70% of cats remaining in the study. During the next 4 weeks, 57, 15 and 22% of cats remaining in the study could be treated at twice a week, every other day or daily, respectively. After the first 4 weeks, the mean lesion score and owner-assessed pruritus improved over baseline by 69 and 61%, respectively, and remained stable during the following 8 weeks. Approximately 65% of the cats in the study were reported to have an adverse event (AE), very often mild and resolving spontaneously. The most frequent AEs were gastrointestinal and included primarily vomiting and diarrhoea. Eighty per cent of AEs occurred when cats were on daily treatment. Conclusions and clinical importance - Results suggest that the induction dose of 7 mg/kg ciclosporin can be tapered as soon as 4 weeks without deterioration of the clinical response. Establishment of the lowest effective dosing regimen of ciclosporin reduced the frequency of AEs.
机译：背景-有关环孢素剂量减量方案和猫过敏性皮炎治疗的临床反应的信息很少。假设/目标-测试剂量减少方案并评估长达18周的疗效和临床安全性。动物-患有猫过敏性皮炎的八十八只客户拥有的猫。方法-每天接受2.5 mg / kg或7 mg / kg安慰剂或环孢素的猫连续6周，每天给予7 mg / kg环孢素4周。根据临床反应，在接下来的4周中，剂量将从每天逐渐减小到每隔一天，然后逐渐增加至每周两次，持续4周。结果-在所有猫接受7 mg / kg的治疗4周后，在剩余的研究中，有70％的猫的剂量可以在接下来的4周中每隔一天逐渐减少。在接下来的4周中，可以分别每周两次，隔天一次或每天两次对研究中剩下的猫中的57％，15％和22％进行治疗。在最初的4周后，平均病变评分和所有者评估的瘙痒比基线分别提高了69％和61％，并且在接下来的8周内保持稳定。据报道，研究中约有65％的猫患有不良事件（AE），通常为轻度且自发解决。最常见的AE是胃肠道的，主要包括呕吐和腹泻。当猫每天接受治疗时，百分之八十的不良事件发生。结论和临床重要性-结果表明，环孢素7 mg / kg的诱导剂量可在4周内逐渐缩小，而不会恶化临床反应。建立环孢菌素的最低有效给药方案可降低AEs的发生频率。

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