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首页> 外文期刊>Vascular surgery >Increased intimal hyperplasia after carotid endarterectomy in spontaneously hypertensive rats.
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Increased intimal hyperplasia after carotid endarterectomy in spontaneously hypertensive rats.

机译：自发性高血压大鼠颈动脉内膜切除术后内膜增生增加。

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This study evaluated the effects of hypertension on postoperative intimal hyperplasia using a rat carotid endarterectomy (CEA) model with spontaneously hypertensive rats (SHR) and normotensive Sprague-Dawley rats (SD). SHR and SD rats underwent left carotid exposure and CEA via an arteriotomy, scoring and removal of the intima, followed by arteriotomy closure. The rats were then sacrificed two weeks postoperatively. The left carotid artery was harvested and underwent elastin and double immunohistochemical staining. The percent of lumenal stenosis was calculated using morphometric measurements, and stained cells within the intimal hyperplasia were counted. The means and standard deviation of the means were calculated, and the two groups were compared using a 2-sample t test. The systolic blood pressure was 228 +/-35 mm Hg in the SHR group and 108 +/-8 mm Hg in the SD group (p<0.00001). The percent of lumenal stenosis was 82.6 +/-17.1% in the SHR group and 21.2 +/-13.7% in the SD rats (p value <0.0001). The percentage of cells staining for a-SM actin was equal in the SHR group and the SD group (> 91%) but the percentage of these cells staining for BrdU was 38.2 +/-8.4% in the SHR group and 10.7 +/-5.8% in the SD group (p< 0.00001). Hypertension in the SHR rats was associated with an increased lumenal stenosis due to increased intimal hyperplasia. The increased intimal hyperplasia was due to enhanced and accelerated replication of smooth muscle cells. Hypertension may be associated with increased restenosis rates after CEA.
机译：这项研究使用自发性高血压大鼠（SHR）和血压正常的Sprague-Dawley大鼠（SD）的大鼠颈动脉内膜切除术（CEA）模型评估了高血压对术后内膜增生的影响。 SHR和SD大鼠通过动脉切开术进行左颈暴露和CEA，对内膜进行评分和去除，然后进行动脉切开术。然后在术后两周处死大鼠。收集左颈动脉并进行弹性蛋白和免疫组织化学双重染色。使用形态测量法计算管腔狭窄的百分比，并计数内膜增生内的染色细胞。计算均值和均值标准偏差，并使用2样本t检验比较两组。 SHR组的收缩压为228 +/- 35 mm Hg，SD组的收缩压为108 +/- 8 mm Hg（p <0.00001）。 SHR组的管腔狭窄百分比为82.6 +/- 17.1％，SD大鼠为21.2 +/- 13.7％（p值<0.0001）。 SHR组和SD组中a-SM肌动蛋白的细胞染色百分率相等（> 91％），但SHR组和BrdU的这些细胞染色百分率分别为38.2 +/- 8.4％和10.7 +/- SD组为5.8％（p <0.00001）。 SHR大鼠的高血压与由于内膜增生增加引起的管腔狭窄增加有关。内膜增生的增加是由于平滑肌细胞复制的增强和加速。高血压可能与CEA后再狭窄率增加有关。

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