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首页> 外文期刊>Veterinary Microbiology >Evaluation of cross-protection against three topotypes of serotype O foot-and-mouth disease virus in pigs vaccinated with multi-epitope protein vaccine incorporated with poly(I:C)
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Evaluation of cross-protection against three topotypes of serotype O foot-and-mouth disease virus in pigs vaccinated with multi-epitope protein vaccine incorporated with poly(I:C)

机译：接种多表位蛋白疫苗并掺有聚（I：C）的猪对三种​​血清型O型口蹄疫疾病交叉保护的评价

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Epitope-based vaccines are always questioned for their cross-protection against the antigenically variable foot-and-mouth disease virus (FMDV). In this study, we proved the cross-protection effect of a multi-epitope vaccine incorporated with poly(I:C) against three topotypes of 0 type FMDV. A total of 45 naive pigs were vaccinated with different doses of multi-epitope protein vaccine incorporated with poly(I:C). At 28 days post-vaccination, 45 vaccinated and 6 unvaccinated control pigs (two pigs for each group) were challenged with three topotypes of virulent 0 type FMDV, namely, O/Mya/98 (Southeast Asia topotype), O/HN/CHA/93 (Cathay topotype) and O/Tibet/CHA/99 (PanAsia topotype) strains. All unvaccinated pigs developed generalised FMD clinical signs. Results showed that all pigs (n = 15) conferred complete protection against the O/Mya/98 and O/HN/CHA/93 FMDV strains, 11 of which were protected against the O/Tibet/CHA/99 FMDV strain. The 50% protective dose values of the vaccine against the O/Mya/98, O/HN/CHA/93 and O/Tibet/CHA/99 FMDV strains were 15.59, 15.59 and 7.05, respectively. Contact challenge experiment showed that transmission occurred from the donors to the unvaccinated but not to vaccinated pigs. These results showed that vaccination with multi-epitope protein vaccine incorporated with poly(I:C) can efficiently prevent FMD in pigs
机译：基于抗原决定簇的疫苗总是受到针对抗原可变性口蹄疫病毒（FMDV）的交叉保护的质疑。在这项研究中，我们证明了掺有聚（I：C）的多表位疫苗对三种0型FMDV拓扑型的交叉保护作用。总共对45只幼稚猪进行了不同剂量的掺有poly（I：C）的多表位蛋白疫苗接种。接种后28天，对45头接种疫苗的猪和6头未接种对照的猪（每组两头猪）进行了3种强毒0型FMDV的拓扑型攻击，即O / Mya / 98（东南亚拓扑型），O / HN / CHA / 93（Cathay拓扑型）和O / Tibet / CHA / 99（泛亚拓扑型）菌株。所有未接种疫苗的猪均出现全身性口蹄疫临床症状。结果显示，所有猪（n = 15）都具有针对O / Mya / 98和O / HN / CHA / 93 FMDV品系的完全保护，其中11具针对O / Tibet / CHA / 99 FMDV品系的保护。疫苗针对O / Mya / 98，O / HN / CHA / 93和O / Tibet / CHA / 99 FMDV株的50％保护剂量值分别为15.59、15.59和7.05。接触攻击实验表明，从供体到未接种疫苗的猪之间发生了传播，但没有发生到未接种疫苗的猪。这些结果表明，多表位蛋白疫苗与聚（I：C）结合疫苗可以有效预防猪的口蹄疫

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