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首页> 外文期刊>Twin research and human genetics : >Genetic and environmental covariations among obsessive-compulsive symptoms, neuroticism, and extraversion in South Korean adolescent and young adult twins.
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Genetic and environmental covariations among obsessive-compulsive symptoms, neuroticism, and extraversion in South Korean adolescent and young adult twins.

机译：强迫症，神经质和外向性在韩国青少年和年轻成年双胞胎之间的遗传和环境协变。

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A growing literature suggests that personality traits may be endophenotype markers for psychiatric illnesses. Although the phenotypic relationships between obsessive-compulsive disorder (OCD) and high neuroticism and low extraversion have been well documented, underlying genetic and environmental contributions to these associations have not been explored previously. Five hundred and twenty-four monozygoitc (MZ) and 228 dizygotic (DZ) pairs of adolescent and young adult twins (aged 13-24 years) drawn from the South Korean Twin Registry completed the Maudsley Obsessive Compulsive Inventory (MOCI) and the Neuroticism and Extraversion scale of the Eysenck Personality Scale by mail. The total score of MOCI (MOCIT) was significantly and positively correlated with Neuroticism (r = .44), but only weakly and negatively related to Extraversion (r = -.10). A trivariate Cholesky model was applied to the data. The additive genetic correlations in the best-fitting model were .51 between Neuroticism and MOCIT and -.17 between Extraversion and MOCIT, suggesting that additive genetic factors that lead to high neuroticism and low extraversion overlap with those genetic factors influencing high OC symptoms. These findings add to the cumulative evidence of the shared genetic etiology for the associations between a personality profile of high neuroticism and low extraversion and mental illnesses.
机译：越来越多的文献表明，人格特质可能是精神疾病的内表型标记。尽管强迫症（OCD）与高度神经质和低外向性之间的表型关系已得到充分证明，但以前尚未探讨这些关联的潜在遗传和环境贡献。从韩国双胞胎登记处抽取的成对双胞胎（MZ）和224对双合子（DZ）的成年和年轻成年双胞胎（年龄13-24岁）对完成了Maudsley强迫症量表（MOCI）以及神经质和埃森克个性量表的外向量表通过邮件发送。 MOCI的总分（MOCIT）与神经质（r = .44）呈显着正相关（r = .44），而与外向性（ex = version）则呈弱和负相关（r = -.10）。将三变量Cholesky模型应用于数据。在最佳拟合模型中，加性遗传相关性在Neuroticism和MOCIT之间为.51，在外向性与MOCIT之间为-.17，这表明导致高神经质和低外向性的加性遗传因素与影响高OC症状的遗传因素重叠。这些发现为具有高度神经质和低外向性的人格特征与精神疾病之间的关联提供了共同的遗传病因学的累积证据。

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