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首页> 外文期刊>Twin research and human genetics : >Depression, Neuroticism, and Urinary Incontinence in Premenopausal Women: A Nationwide Twin Study
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Depression, Neuroticism, and Urinary Incontinence in Premenopausal Women: A Nationwide Twin Study

机译：绝经前妇女的抑郁症，神经质和尿失禁：全国双生子研究

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Previous studies have found that major depression and neuroticism are positively associated with urinary incontinence (Ul). However, the genetic contribution to these associations has never been investigated. In 2005, a total of 14,094 female twins born 1959-1985 in the Swedish Twin Registry participated in a comprehensive survey on common exposures and complex diseases. Structured questions provided information on Ul, depressive symptoms, major depression, and neuroticism. A logistic regression model based on generalized estimating equations (GEE) was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs). Environmental and genetic influences were assessed in co-twin control analyses and quantitative genetic analyses, which were also used to determine the proportion of the phenotypic correlation explained by familial factors. Major depression, depressive symptoms, and neuroticism were positively associated with all Ul subtypes (overall, stress, urge, and mixed Ul). In a trivariate Cholesky model with neuroticism, depressive symptoms (or depression), and Ul a modest genetic correlation was found between indicators of depression and overall, or stress, Ul. The majority of this correlation was independent from neuroticism. In contrast, the genetic factors shared between indicators of depression and urge or mixed Ul were entirely in common with neuroticism. In conclusion, depression and neuroticism are associated with Ul among premenopausal women: the associations are in part determined by genetic factors in common to the disorders.
机译：先前的研究发现，严重的抑郁症和神经质与尿失禁（Ul）正相关。但是，从未研究过对这些关联的遗传贡献。 2005年，在瑞典双胞胎登记处出生的1959-1985年间，共有14,094名女性双胞胎参加了关于常见暴露和复杂疾病的综合调查。结构性问题提供了有关Ul，抑郁症状，严重抑郁和神经质的信息。使用基于广义估计方程（GEE）的逻辑回归模型估计具有95％置信区间（CI）的比值比（OR）。在双胞胎对照分析和定量遗传分析中评估了环境和遗传影响，还用于确定由家族因素解释的表型相关性的比例。严重的抑郁，抑郁症状和神经质与所有Ul亚型（总体，压力，冲动和混合性Ul）呈正相关。在具有神经质，抑郁症状（或抑郁）和Ul的三变量Cholesky模型中，发现抑郁指标与总体或压力Ul指标之间存在适度的遗传相关性。这种关联的大部分与神经质无关。相比之下，抑郁症和冲动或混合性Ul指标之间共享的遗传因素与神经质完全相同。总之，绝经前女性的抑郁症和神经质与Ul病有关：这种关系部分由疾病常见的遗传因素决定。

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