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首页> 外文期刊>Veterinarni Medicina >Alpha-tocopherol and hepatic parameters in dairy cows with liver failure.
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Alpha-tocopherol and hepatic parameters in dairy cows with liver failure.

机译：肝衰竭奶牛的α-生育酚和肝参数。

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Forty-five Holstein-Friesian dairy cows with left displacement of abomasum were used in the present study. After surgery the cows were divided into two groups: A - cows with liver failure (n = 15) and B - cows without liver failure (controls; n = 30). The diagnosis of hepatic failure was based on clinical signs (symptoms of hepatic encephalopathy) and on laboratory analyses of ammonia concentration > 30μmol/litre and of amino acid-index < 4.0 (valine + leucine + isoleucine/tyrosine + phenylalanine). The cows with liver failure did not differ significantly from controls in both liver triglyceride and glycogen contents. Serum levels of total bilirubin, AST, GLDH and GGT were higher and of cholesterol were lower in cows with hepatic failure than incontrols. There were no significant differences in FFA and BHB mean serum concentrations between the groups. The cows with liver failure were clearly deficient in plasma alpha-tocopherol levels that were significantly lower in comparison with the controlcows (0.91 ± 0.12 mg/litre, 1.82 ± 0.13 mg/litre, respectively). It is concluded that the clear vitamin E deficiency in dairy cows suffering from hepatic failure could increase the risk of uncontrolled lipid peroxidative processes in the liver and thuslead to severe tissue damage.
机译：在本研究中使用了45只荷斯坦厌恶的荷斯坦-弗里斯兰奶牛。手术后，将母牛分为两组：A-出现肝衰竭的母牛（n = 15）和B-没有肝衰竭的母牛（对照组; n = 30）。肝功能衰竭的诊断是基于临床体征（肝性脑病的症状）和对氨气浓度>30μmol/ L和氨基酸指数<4.0（缬氨酸+亮氨酸+异亮氨酸/酪氨酸+苯丙氨酸）的实验室分析。肝衰竭的奶牛的甘油三酸酯和糖原含量与对照组无显着差异。与对照组相比，患有肝衰竭的母牛的血清总胆红素，AST，GLDH和GGT较高，胆固醇较低。两组之间的FFA和BHB平均血清浓度无显着差异。肝衰竭的奶牛血浆α-生育酚水平明显不足，与对照组相比，血浆α-生育酚水平显着降低（分别为0.91±0.12 mg / L，1.82±0.13 mg / L）。结论是，患有肝衰竭的奶牛中明显的维生素E缺乏会增加肝脏中脂质过氧化过程失控的风险，从而导致严重的组织损伤。

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