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首页> 外文期刊>Veterinarni Medicina >Evaluation of the activity of intraarticular hyaluronic acid in the repair of experimentally induced osteochondral defects of the stifle joint in dogs.
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Evaluation of the activity of intraarticular hyaluronic acid in the repair of experimentally induced osteochondral defects of the stifle joint in dogs.

机译：评价关节内透明质酸在修复实验性诱发的狗窒息性关节软骨缺损中的活性。

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摘要

The present study examined the results of using hyaluronic acid with autogenetic cancellous grafts in the treatment of experimentally induced osteochondral defects in the stifle joints of dogs. In this study, 10 mature dogs of different breeds, weights and of both sexes were used. General anesthesia and usual operation procedures were followed. A 10 mm deep defect was created on the femoral sulcus of the trochlea with a drill tip of 8 mm in diameter. The defects in the right and left legs were filled with autogenic cancellous grafts taken from the metaphysial region of the tibia. The left legs constituted the experimental group while the right legs served as control group. In the experimental group, 2 mg/kg intraarticular hyaluronic acid was twice administered into the stifle joint, i.e., immediately subsequent to the operation and 1 month afterwards. Parenteral antibiotics were prescribed postoperatively for ten days. Five animals were sacrificed at the third and sixth month after surgery. Macroscopic and microscopic findings obtained from each case were evaluated. On macroscopical examination, trochlear defects were determined to be incompletely filled at the third month in both control and experimental groups. On histopathologic examination, a loose fibrovascular formation in the area where the graft was applied was observed to be present in both control and experimental groups. However, in the experimental group this formation was more superficial, ossification activity was greater and trabeculous bone formation had been initiated. Macroscopical examination carried out in the sixth month determined that in the control group the defect surface did not fill up to the trochlear sulcus level. In the histopathologic examination, in control groups it was found that fibrocartilageous structures were developing in the fibrovascular space even though ossification was incomplete. The macroscopic examination showed that in the experimental group, the defect surface reached the trochlear sulcus level of defects in this month. The histopatologic examination revealed that fibrous tissue comprised a thin layer, under which ossification processes were complete and bone trabeculates fully formed. It was concluded that the usage of autogenic cancellous graft along with hyaluronic acid may be useful in the repair of large osteochondral defects.
机译：本研究检查了将透明质酸与自体松质移植物一起用于治疗实验性诱导的狗膝关节骨软骨缺损的结果。在这项研究中，使用了10个不同品种，体重和性别的成年犬。遵循全身麻醉和常规手术程序。用直径8 mm的钻尖在滑车的股沟上形成10 mm深的缺损。右腿和左腿的缺损处充满了取自胫骨干physi端的自体松质移植物。左腿为实验组，右腿为对照组。在实验组中，将2mg / kg的关节内透明质酸两次施用于窒息关节，即在手术后立即且在术后1个月。术后处方非肠道抗生素十天。在手术后的第三和第六个月处死五只动物。评估从每个案例获得的宏观和微观发现。通过肉眼检查，在对照组和实验组中，第三个月的滑车缺陷被确定为未完全填充。在组织病理学检查中，在对照组和实验组中均观察到在应用移植物的区域中存在松散的纤维血管形成。然而，在实验组中，这种形成更浅，骨化活性更大，并且已经开始了小梁的形成。在第六个月进行的宏观检查确定，对照组的缺损表面未填满滑车沟水平。在组织病理学检查中，在对照组中，尽管骨化不完全，但仍在纤维血管空间中形成了纤维软骨结构。宏观检查表明，实验组缺损表面在本月达到滑车沟的缺损水平。组织病理学检查显示，纤维组织包括薄层，在该薄层下，骨化过程完成，并且骨小梁完全形成。结论是自体松质骨移植物与透明质酸一起使用可能对大骨软骨缺损的修复有用。

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