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首页> 外文期刊>Veterinarni Medicina >Susceptibility of selected murine and microtine species to infection by a wild strain of Francisella tularensis subsp, holoarctica.
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Susceptibility of selected murine and microtine species to infection by a wild strain of Francisella tularensis subsp, holoarctica.

机译：选定的鼠类和微类物种易受图拉尼弗朗西斯菌亚种，> arocarctica 。

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摘要

The purpose of this study was to compare susceptibility of BALB/c mice, common voles (Microtus arvalis) and yellow-necked mice (Apodemus flavicollis) to infection by a virulent Francisella tularensis subsp. holarctica strain. Median survival in these three species following experimental infection with 320 colony forming units of F. tularensis (both intraperitoneally and subcutaneously) amounted to 4.5, 7 and 4 days, respectively. Survival curves of BALB/c and yellow-necked mice were very similar and were significantly different from that of common voles. LD50 was 0.5 and 37.9 colony forming units in BALB/c mice and common voles, respectively. The bacterial burden in the spleen, liver, lung, kidney and blood of common voles started to develop later post exposure and amounted to lower levels (except in kidneys) than in BALB/c mice. The results demonstrate that yellow-necked mice are even more susceptible to infection by E. tularensis than BALB/c mice and that the common vole is a small mammalian host with a susceptibility which is two-orders-of-magnitude lower.
机译：这项研究的目的是比较BALB / c小鼠，普通田鼠（ Microtus arvalis ）和黄颈小鼠（ Apodemus flavicollis ）对强力< i>土拉弗朗西斯菌亚种 holarctica 菌株。用320 F集落形成单位进行实验性感染后，这三个物种的中位生存期。 tularensis （腹膜内和皮下）分别为4.5天，7天和4天。 BALB / c和黄颈小鼠的存活曲线非常相似，并且与普通田鼠的存活曲线显着不同。在BALB / c小鼠和普通田鼠中，LD 50 分别为0.5和37.9个菌落形成单位。普通田鼠的脾脏，肝脏，肺脏，肾脏和血液中的细菌负荷在接触后开始发展，并且其水平（除肾脏外）低于BALB / c小鼠。结果表明，黄颈小鼠甚至更易受E感染。 tularensis 比BALB / c小鼠更常见，并且普通田鼠是小型哺乳动物宿主，易感性低了两个数量级。

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