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首页> 外文期刊>Veterinary Ophthalmology >The effects of ketamine-midazolam anesthesia on intraocular pressure in clinically normal dogs
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The effects of ketamine-midazolam anesthesia on intraocular pressure in clinically normal dogs

机译：氯胺酮-咪达唑仑麻醉对临床正常犬眼压的影响

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To determine the effects of intravenous ketamine-midazolam anesthesia on intraocular pressure (IOP) in ocular normotensive dogs. Thirteen adult mixed-breed dogs. Dogs were randomly assigned to treatment (n = 7) and control (n = 6) groups. Dogs in the treatment group received intravenous ketamine 15 mg/kg and midazolam 0.2 mg/kg and dogs in the control group received intravenous saline. The time of intravenous drug injection was recorded (T). Measurements of IOP were then repeated 5 min (T) and 20 min (T) following the intravenous administration of ketamine-midazolam combination and saline in both groups. Measurements showed normal IOP values in both groups. The mean pl SD baseline IOP values for treatment and control groups were 13.00 pl 1.47 and 10.33 pl 2.20, respectively. For baseline IOP values, there was no significant difference between treatment and control groups (P = 0.162). In the treatment group, the subsequent post-treatment mean pl SD values were 15.64 pl 2.17 (5 min), and 14.92 pl 1.98 (20 min). There was no evidence of statistical difference between baseline values and post-treatment values after treatment with ketamine-midazolam (P = 0.139; P = 0.442). In control eyes, the mean pl SD values at 5 and 20 min were 10.41 pl 2.01 and 10.16 pl 1.69, respectively. There was no significant difference between baseline values and post-treatment values in control group (P = 1.000; P = 1.000). Ketamine-midazolam combination has no clinically significant effect on IOP in the dog.
机译：要确定静脉氯胺酮-咪达唑仑麻醉对高眼压犬眼压（IOP）的影响。十三只成年杂种犬。将狗随机分为治疗组（n = 7）和对照组（n = 6）。治疗组的狗静脉注射氯胺酮15 mg / kg和咪达唑仑0.2 mg / kg，对照组的狗静脉注射生理盐水。记录静脉注射药物的时间（T）。在两组中分别静脉注射氯胺酮-咪达唑仑和生理盐水后，分别于5分钟（T）和20分钟（T）重复测量IOP。测量结果显示两组的正常IOP值。治疗组和对照组的平均pl SD基线IOP值分别为13.00 pl 1.47和10.33 pl 2.20。对于基线眼压值，治疗组和对照组之间无显着差异（P = 0.162）。在治疗组中，随后的治疗后平均pl SD值为15.64 pl 2.17（5分钟）和14.92 pl 1.98（20分钟）。氯胺酮-咪达唑仑治疗后，基线值和治疗后值之间没有统计学差异（P = 0.139; P = 0.442）。在对照眼中，在5分钟和20分钟时的平均pl SD值分别为10.41 pl 2.01和10.16 pl 1.69。对照组的基线值和治疗后值之间无显着差异（P = 1.000; P = 1.000）。氯胺酮-咪达唑仑的组合对狗的眼压没有临床意义。

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