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Efficacy of topically applied liposome-bound tetracycline in the treatment of dry eye model

机译：局部应用脂质体结合的四环素治疗干眼症的功效

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ObjectiveTo evaluate the effects of liposome-bound tetracycline eye drops in a rabbit dry eye model evaluating their advantage of being less allergic, preservative free and prolonged action compared with other tear substitutes.ProceduresNew Zealand albino rabbits were equally divided into control group and dry eye induced groups. Dryness was induced in 24 eyes of 12 healthy adult male albino rabbits by instilling atropine sulfate eye drops 1% three times daily for 1 week, then animals were subdivided into four groups; group 1 (rabbits with dry eye model), groups 2, 3, and 4: rabbits with dry eye model treated for 7 days starting on 7th day of dryness induction with either tetracycline, empty liposome, or combined tetracycline with liposome as topical eye drops respectively. Schirmer (STT) test and tear break up time (TBUT) were assessed on days 0, 2, 4, 7, 9, 11, and 14. Animals were sacrificed on day 14 and histopathological examination of the cornea and conjunctiva was performed.ResultsTear break up time and STT test values were significantly improved in groups 2, 3, 4 as compared with group 1. The histopathological examination showed normal cytoarchitecture of corneas and conjunctivae in groups 2, 3, 4 against the dryness effect that continued to affect the cornea and conjunctival epithelium in group 1. There was a significant improvement in the group treated with liposome-bound tetracycline eye drops (group 4) as compared with tetracycline alone (group 2) and empty liposome (group 3).ConclusionThe use of liposome encapsulated tetracycline significantly improved STT and TBUT values as well as reverse surface ocular pathology.
机译：目的评估脂质体结合的四环素滴眼液在兔干眼模型中的作用，以评估与其他泪液替代品相比，其过敏性，防腐剂游离少和作用时间长的优势。程序将新西兰白化兔分为对照组和干眼诱导大鼠组。通过每天3次每天1次滴入1％硫酸阿托品眼滴眼液，在12只健康的成年雄性白化兔子的24只眼中诱发干燥，然后将动物分为四组;每组1只。第1组（具有干眼模型的兔子），第2、3和4组：具有干眼模型的兔子从诱导干燥的第7天开始，以四环素，空脂质体或四环素与脂质体联合作为局部滴眼剂治疗7天分别。在第0、2、4、7、9、11和14天评估Schirmer（STT）测试和撕裂时间（TBUT），在第14天处死动物并进行角膜和结膜的组织病理学检查。与第1组相比，第2、3、4组的解体时间和STT测试值均得到了显着改善。组织病理学检查显示，第2、3、4组中角膜和结膜的细胞结构正常，而干燥作用继续影响角膜和结膜上皮在第1组中。与单独用四环素（第2组）和空脂质体（第3组）相比，用脂质体结合的四环素滴眼液（第4组）治疗组有显着改善。结论使用脂质体包裹的四环素显着改善了STT和TBUT值以及反面眼部病理。

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