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首页> 外文期刊>Veterinary Parasitology >Blocking Fasciola hepatica's energy metabolism - a pilot study of vaccine potential of a novel gene - phosphoglycerate kinase.
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Blocking Fasciola hepatica's energy metabolism - a pilot study of vaccine potential of a novel gene - phosphoglycerate kinase.

机译:阻断肝大肠埃希菌的能量代谢-一种新基因-磷酸甘油酸激酶的疫苗潜力的初步研究。

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摘要

Fasciola hepatica infections cause huge economic losses to livestock production and are a serious problem in human and veterinary medicine. The main difficulty in the control of infections is progressing drug resistance. Moreover, pharmacological therapy is expensive and harmful for the environment. The best way of prophylaxis against infections seems to be vaccination. A new generation of vaccines could be the best possible way of controlling fasciolosis. This paper is focused on first vaccination trials based on a new vaccine candidate antigen, F. hepatica phosphoglycerate kinase (FhPGK) performed on a rat model. We obtained protection levels ranging from 0% to 69% depending on the way of delivery and form of vaccine.
机译:肝炎Fasciola hepatica 感染给牲畜生产造成巨大的经济损失,是人类和兽医学中的一个严重问题。控制感染的主要困难是耐药性的发展。而且,药物疗法昂贵并且对环境有害。预防感染的最佳方法似乎是接种疫苗。新一代疫苗可能是控制筋膜炎的最佳方法。本文的重点是基于新疫苗候选抗原 F的首次疫苗接种试验。肝磷酸甘油酸激酶(FhPGK)在大鼠模型上进行。根据疫苗的递送方式和形式,我们获得的保护水平为0%至69%。

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