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首页> 外文期刊>Veterinary Parasitology >Anticoccidial efficacy of naringenin and a grapefruit peel extract in growing lambs naturally-infected with Eimeria spp.
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Anticoccidial efficacy of naringenin and a grapefruit peel extract in growing lambs naturally-infected with Eimeria spp.

机译：柚皮苷和柚子皮提取物对天然感染艾美球虫属的羔羊的抗球虫功效。

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The current study aimed to determine the anti-Eimeria efficacy of an extract of grapefruit peels (GF) and commercial naringenin (NAR) in naturally-infected lambs, as well as the influence of these flavonoids on the oxidative status during ovine coccidiosis. Pharmacokinetic profiles were also determined. Extracts were administered per os to Eimeria naturally infected growing lambs during 90 consecutive days. The commercial anticoccidial drug toltrazuril (TTZ) was included in this trial as a standard. Twenty-four lambs were divided into four groups: NAR, lambs given a daily dose of 5 mg of a commercial naringenin extract of 98% higher purity per kg body weight; GF, lambs that recived a daily dose of 5 mg of ethanolic extract of grapefruit peels per kg body weight; TTZ, lambs treated with 20 mg of toltrazuril/kg body weight on days 0 and 15 of the experiment; and CTRL, untreated lambs that received daily dose of 30 ml of water. Daily doses of GF and NAR were dissolved in 30 ml of water and orally given to animals; whereas toltrazuril was administered as a single dose of an undiluted suspension to lambs of the TTZ group. The CTRL group received 30 nil of water; as well as the TTZ group for the period after the single dose administration. Fecal and serum samples were collected from all lambs. Anticoccidial efficacy was estimated by coprological techniques. Generation of nitric oxide levels and the antioxidant capacity of the experimental compounds were determined by the Griess and ABTS assays, respectively. The pharmacokinetic parameters of NAR and the GF extract were obtained. On day 30 post-ingestion, anticoccidial efficacy was 91.76% (NAR) and 89.65% (GF); whereas 99.63% of efficacy was achieved with TTZ 15 days after treatment. NAR, GF and TTZ significantly reduced oxidative stress in infected animals. The mean daily weight gain for each group was 122 g (NAR), 122 g (GF), 143 g (TTZ) and 98 g (GIRL). Following the oral administration of NAR and GF, values in plasma approached maximum concentrations within 2.1 to 2.5 h. In conclusion, the administration of NAR and the GF extract reduced Eimeria oocyst output, oxidative stress and promoted higher mean daily weight gains in infected lambs. (C) 2016 Elsevier B.V. All rights reserved.
机译：当前的研究旨在确定葡萄柚皮（GF）和市售柚皮素（NAR）提取物在自然感染的羔羊中的抗艾美体功效，以及这些类黄酮对绵羊球虫病期间氧化状态的影响。还确定了药代动力学特征。在连续90天内，将提取物经口服给药于艾美球虫自然感染的成长羔羊。商业抗球虫药物托曲脲（TTZ）已作为标准纳入该试验。将二十四只小羊分为四组：NAR，每只小羊每天给予5毫克的商业柚皮素提取物，每公斤体重的纯度提高98％。 GF，每公斤体重每天摄入5毫克葡萄柚皮乙醇提取物的小羊羔; TTZ，在实验的第0天和第15天用20 mg托曲唑/ kg体重处理的羔羊;和CTRL，未经处理的羔羊，每天接受30毫升水的剂量。将每日剂量的GF和NAR溶于30 ml水中，并口服给予动物; TTZ组的羔羊则以未稀释的悬浮液单次给药的形式给予托曲脲。 CTRL组收到了30毫升水;以及单剂量给药后的TTZ组。从所有羔羊收集粪便和血清样品。通过球菌技术评估抗球虫功效。一氧化氮水平的产生和实验化合物的抗氧化能力分别通过Griess和ABTS测定法确定。获得了NAR和GF提取物的药代动力学参数。注射后第30天，抗球虫药效力为91.76％（NAR）和89.65％（GF）;治疗15天后使用TTZ可获得99.63％的疗效。 NAR，GF和TTZ可显着降低感染动物的氧化应激。每组的平均每日体重增加为122 g（NAR），122 g（GF），143 g（TTZ）和98 g（GIRL）。口服NAR和GF后，血浆中的值在2.1至2.5小时内达到最大浓度。总之，使用NAR和GF提取物可减少艾美球虫卵囊的产量，氧化应激并促进受感染羔羊的平均日增重。 （C）2016 Elsevier B.V.保留所有权利。

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