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首页> 外文期刊>Veterinary Pathology >Diagnostic immunohistochemistry of canine and feline intracalvarial tumors in the age of brain biopsies. (Special Focus: Investigative techniques.)
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Diagnostic immunohistochemistry of canine and feline intracalvarial tumors in the age of brain biopsies. (Special Focus: Investigative techniques.)

机译：在脑活检年龄的犬和猫颅内肿瘤的诊断性免疫组织化学。 （特别关注：调查技术。）

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摘要

The focus of immunohistochemistry as applied to nervous system tumors is in identifying the neoplasm present and evaluating margins between normal and neoplastic tissue. Although not always utilized by specialists in neuropathology, immunohistochemistry remains useful to resolve concerns about the differentiation and rate of tumor growth. The aims of this review are to discuss the utility of immunohistochemical reagents currently used in diagnosis of canine and feline intracalvarial tumors, to indicate the applicability of some tests currently used in human nervous system tumors for domestic species, and to evaluate a few less commonly used reagents. A panel of biomarkers is usually needed to confirm a diagnosis, with groups of reagents for leptomeningeal, intraparenchymal, and ventricular neoplasms. In the future, signature genetic alterations found among feline and canine brain tumors - as correlated prospectively with diagnosis, rate of enlargement, or response to treatment - may result in new immunohistochemical reagents to simplify the task of diagnosis. Prospective studies determining the type and proportion of stem cell marker expression on patient longevity are likely to be fruitful and suggest new therapies. Due to increased frequency of biopsy or partial resection of tumors from the living patient, biomarkers are needed to serve as accurate prognostic indicators and assist in determining the efficacy of developing therapeutic options in nervous system tumors of dogs and cats.
机译：免疫组织化学应用于神经系统肿瘤的重点是鉴定存在的肿瘤并评估正常组织与肿瘤组织之间的边界。尽管神经病理学专家并不总是使用免疫组化，但免疫组织化学仍然可以解决有关肿瘤分化和生长速率的问题。这篇综述的目的是讨论目前用于诊断犬和猫颅内肿瘤的免疫组织化学试剂的实用性，以表明目前在人类神经系统肿瘤中使用的某些检测方法对家养物种的适用性，并评估一些不常用的检测方法试剂。通常需要一组生物标志物来确认诊断，其中包括用于软脑膜，实质内和心室肿瘤的试剂组。将来，在猫和犬脑肿瘤中发现的标志性基因改变-与诊断，扩大率或对治疗的反应相关，可能会产生新的免疫组化试剂以简化诊断任务。确定干细胞标志物表达类型和比例以延长患者寿命的前瞻性研究可能会富有成果，并提出了新的治疗方法。由于活检患者活检或部分切除肿瘤的频率增加，因此需要生物标记物作为准确的预后指标，并帮助确定在猫和猫的神经系统肿瘤中发展治疗选择的功效。

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