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首页> 外文期刊>Veterinary Radiology & Ultrasound >COMPARISON OF CLOSURE TIMES FOR CRANIAL BASE SYNCHONDROSES IN MESATICEPHALIC, BRACHYCEPHALIC, AND CAVALIER KING CHARLES SPANIEL DOGS
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COMPARISON OF CLOSURE TIMES FOR CRANIAL BASE SYNCHONDROSES IN MESATICEPHALIC, BRACHYCEPHALIC, AND CAVALIER KING CHARLES SPANIEL DOGS

机译：中齿，腕足和骑士查理犬狗颅底同步闭合时间的比较

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摘要

Premature closure of cranial base synchondroses has been proposed as the mechanism for brachycephaly in dogs and caudal occipital malformation syndrome (COMS) in Cavalier King Charles Spaniels. The purpose of this retrospective study was to compare times of closure for cranial base synchondroses in mesaticephalic, brachycephalic, and Cavalier King Charles Spaniel dogs. Cranial magnetic resonance imaging studies were retrieved for client-owned dogs less than 18 months of age. Breed, age, skull conformation, and the open or closed state of cranial base synchondroses were independently recorded by two observers. For dogs with a unanimous observer agreement, regression analysis was used to test effects of age and gender on the open or closed status of synchondroses and differences between groups. A total of 174 dogs were included in MRI interpretations and 165 dogs were included in the regression analysis. Statistically significant differences in closure time of the spheno-occipital synchondrosis were identified between brachycephalic and mesaticephalic dogs (P = 0.016), Cavalier King Charles Spaniels and mesaticephalic dogs (P < 0.0001), and Cavalier King Charles Spaniels and brachycephalic dogs (P = 0.014). Findings from the current study supported the theory that morphological changes leading to the skull phenotype of the Cavalier King Charles Spaniels could be due to an earlier closure of the spheno-occipital synchondrosis.
机译：有人提出过早关闭颅底软骨病是狗的短头畸形和骑士国王查尔斯猎犬的尾枕枕畸形综合症（COMS）的机制。这项回顾性研究的目的是比较中脑型，头颅型和查尔斯国王西班牙猎狗犬的颅底合软骨闭合时间。对年龄小于18个月的客户拥有的狗进行了颅磁共振成像研究。两名观察员分别记录了其品种，年龄，颅骨构象以及颅底关节软骨的开放或闭合状态。对于具有一致观察者同意的狗，使用回归分析来测试年龄和性别对共生软骨的开放或闭合状态以及组间差异的影响。 MRI解释中总共包括了174条狗，而回归分析中包括了165条狗。在短头和中头狗（P = 0.016），查尔斯国王西班牙猎狗和中头狗（P <0.0001），骑士查尔斯国王西班牙猎狗和短头狗之间，蝶枕合软骨闭合时间的统计学差异显着。 ）。来自当前研究的发现支持了这一理论，即导致骑士查尔斯国王西班牙猎狗头骨形态出现的形态变化可能是由于蝶枕枕合软骨的早期闭合所致。

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