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首页> 外文期刊>Veterinary Radiology & Ultrasound >FEASIBILITY FOR MAPPING CARTILAGE T1 RELAXATION TIMES IN THE DISTAL METACARPUS3/METATARSUS3 OF THOROUGHBRED RACEHORSES USING DELAYED GADOLINIUM-ENHANCED MAGNETIC RESONANCE IMAGING OF CARTILAGE (dGEMRIC): NORMAL CADAVER STUDY
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FEASIBILITY FOR MAPPING CARTILAGE T1 RELAXATION TIMES IN THE DISTAL METACARPUS3/METATARSUS3 OF THOROUGHBRED RACEHORSES USING DELAYED GADOLINIUM-ENHANCED MAGNETIC RESONANCE IMAGING OF CARTILAGE (dGEMRIC): NORMAL CADAVER STUDY

机译：利用延迟的ADO增强磁场磁共振成像（dGEMRIC）映射Thoroubeded Racehors的远端METACARPUS3 / METATARSUS3中的T1弛豫时间的可行性：正常CADAVER研究

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摘要

Osteoarthritis of the metacarpo/metatarsophalangeal joints is one of the major causes of poor performance in horses. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) may be a useful technique for noninvasively quantifying articular cartilage damage in horses. The purpose of this study was to describe dGEMRIC characteristics of the distal metacarpus3/metatarsus3 (Mc3/Mt3) articular cartilage in 20 cadaver specimens collected from normal Thoroughbred horses. For each specimen, T1 relaxation time was measured from scans acquired precontrast and at 30, 60, 120, and 180 min post intraarticular injection of Gd-DTPA(2-) (dGEMRIC series). For each scan, T1 relaxation times were calculated using five regions of interest (sites 1-5) in the cartilage. For all sites, a significant decrease in T1 relaxation times occurred between precontrast scans and 30, 60, 120, and 180 min scans of the dGEMRIC series (P < 0.0001). A significant increase in T1 relaxation times occurred between 60 and 180 min and between 120 and 180 min post Gd injection for all sites. For sites 1-4, a significant increase in T1 relaxation time occurred between 30 and 180 min postinjection (P < 0.05). Sites 1-5 differed significantly among one another for all times (P < 0.0001). Findings from this cadaver study indicated that dGEMRIC using intraarticular Gd-DTPA(2-) is a feasible technique for measuring and mapping changes in T1 relaxation times in equine metacarpo/metatarsophalangeal joint cartilage. Optimal times for postcontrast scans were 60-120 min. Future studies are needed to determine whether these findings are reproducible in live horses
机译：掌指骨/掌指骨关节的骨关节炎是马匹表现不佳的主要原因之一。延迟g增强的磁共振磁共振成像（dGEMRIC）可能是无创地量化马关节软骨损伤的有用技术。这项研究的目的是描述从正常纯种马收集的20具尸体标本中的远端掌骨3 / metatarsus3（Mc3 / Mt3）关节软骨的dGEMRIC特征。对于每个标本，T1弛豫时间是从对比扫描前和关节内注射Gd-DTPA（2-）（dGEMRIC系列）后30、60、120和180分钟获得的扫描测量的。对于每次扫描，使用软骨中的五个感兴趣区域（位置1-5）计算T1松弛时间。对于所有部位，在对比前扫描与dGEMRIC系列的30、60、120和180分钟扫描之间，T1弛豫时间显着减少（P <0.0001）。 T1弛豫时间的显着增加发生在Gd注射后60至180分钟之间以及所有部位120至180分钟之间。对于位置1-4，在注射后30至180分钟之间，T1弛豫时间显着增加（P <0.05）。站点1-5在所有时间之间都存在显着差异（P <0.0001）。该尸体研究的结果表明，使用关节内Gd-DTPA（2-）进行的dGEMRIC是一种可行的技术，可用于测量和标测马掌/间指关节软骨中T1弛豫时间的变化。对比后扫描的最佳时间为60-120分钟。需要进行进一步的研究以确定这些发现在活马中是否可重现

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