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首页> 外文期刊>Virchows Archiv: an international journal of pathology >A benign neoplasm with histopathological features of both schwannoma and retiform perineurioma (benign schwannoma-perineurioma): a report of six cases of a distinctive soft tissue tumor with a predilection for the fingers.
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A benign neoplasm with histopathological features of both schwannoma and retiform perineurioma (benign schwannoma-perineurioma): a report of six cases of a distinctive soft tissue tumor with a predilection for the fingers.

机译：具有神经鞘瘤和网状神经鞘瘤（良性神经鞘瘤-良性神经瘤）的组织病理学特征的良性肿瘤：报告六例特殊的软组织肿瘤，以手指为好。

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摘要

We present six cases of a distinctive soft tissue tumor which occurred in five women and one man. None of the patients had signs of neurofibromatosis. All tumors occurred on the fingers ( n=5) or the thenar eminence of the hand ( n=1). The mean age of the patients was 33 years. The tumors were 1-2.5 cm in diameter (mean size 1.6 cm). Three patients with follow-up were without signs of recurrence or metastasis. Microscopically the lesions were nonencapsulated and featured a multilobular architecture and both myxoid and pseudocystic change. The lobules varied in size and shape and were separated by variably thickened, dense, sclerotic/collagenous septae. The lobules were composed of two components: schwannomatous and perineuriomatous. The schwannomatous component was immunohistochemically S-100 protein positive and CD34 and EMA negative, and the perineuriomatous component had the appearance of retiform perineurioma. The perineurial parts were mostly S-100 protein and CD34 negative and EMA positive. Thesetwo components either formed separate nodules or the schwannomatous tissue surrounded the perineurial parts located in the centers of the lobules. We interpreted the lesions as hybrid tumors with features of schwannoma and retiform perineurioma.
机译：我们介绍了六例特殊的软组织肿瘤，分别发生在五名女性和一名男性中。没有患者有神经纤维瘤病的迹象。所有肿瘤均发生在手指上（n = 5）或手的鼻翼突出（n = 1）。患者的平均年龄为33岁。肿瘤直径为1-2.5cm（平均尺寸为1.6cm）。 3例随访患者无复发或转移迹象。在显微镜下，病变未包囊，具有多叶结构，粘液样和假性囊变。小叶的大小和形状各不相同，并由变厚，致密，硬化/胶原质的隔膜分开。小叶由两部分组成：神经鞘瘤和神经周围瘤。神经鞘瘤成分免疫组织化学检测为S-100蛋白阳性，CD34和EMA阴性，而神经周围瘤成分具有网状视网膜神经瘤的外观。尿道周围部分大部分为S-100蛋白，CD34阴性，EMA阳性。这两个成分要么形成单独的结节，要么是位于小叶中心的神经周部分周围的神经鞘瘤组织。我们将病变解释为具有神经鞘瘤和网状视网膜神经瘤特征的混合型肿瘤。

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