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首页> 外文期刊>Virchows Archiv: an international journal of pathology >The times have changed: molecular pathology is here to stay. A commentary on: analytical performance of a PCR assay for the detection of KRAS mutations (codons 12/13 and 61) in formalin-fixed paraffin-embedded tissue samples of colorectal carcinoma, by Lee et al. In this issue.
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The times have changed: molecular pathology is here to stay. A commentary on: analytical performance of a PCR assay for the detection of KRAS mutations (codons 12/13 and 61) in formalin-fixed paraffin-embedded tissue samples of colorectal carcinoma, by Lee et al. In this issue.

机译：时代已经改变：分子病理学将继续存在。 Lee等人的评论：PCR检测法在大肠癌福尔马林固定石蜡包埋的组织样品中检测KRAS突变（密码子12/13和61）的分析性能。在这个问题上。

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Molecular pathology is now an integral part of diagnostic pathology. This has brought excitement and responsibilities to us as pathologists and molecular biologists in pathology-excitement, due to the many new possibilities we have for diagnosis, prediction of outcome, and response to therapy of disease, and responsibilities, since we need to perform the tests with high accuracy, which requires expertise. But is this different from conventional histology and immunohisto-chemistry? At the time of Virchow, histopathology brought about enormous excitement, and as we are all aware, the responsibilities became rapidly clear. The first attempt to diagnose a tumor in 1882, on a biopsy of a Crown Prince, resulted in a failure, which led to many publications on this topic. Many of us remember the early days of immunohistochemistry, again enormous excitement, many publications (still ongoing) on its use, and obviously, great responsibilities since without immunohistochemistry, many diagnoses are impossible or, at the least, unreliable. But the pathologists looking down the microscope remained the final decision makers. And we all know that a good pathologist can make a correct diagnosis on a poor slide and/or a poor immunostained slide, but without knowledge and experience, even the best slide does not suffice. For molecular pathology, it is different.
机译：分子病理学现已成为诊断病理学不可或缺的一部分。作为病理学家和分子生物学家，这给我们带来了兴奋和责任，这是由于我们需要进行检测，诊断，预测结果，对疾病的治疗做出新的可能，以及责任，因为我们需要进行测试高精度，这需要专业知识。但这与常规组织学和免疫组织化学有何不同？在维尔乔（Virchow）时代，组织病理学引起了极大的兴奋，众所周知，责任已迅速明确。 1882年，在对王储进行活检时首次尝试诊断肿瘤的尝试失败，导致了许多有关此主题的出版物。我们中的许多人都记得免疫组织化学的早期，再度令人兴奋，许多关于其使用的出版物（仍在进行中），而且显然责任重大，因为没有免疫组织化学，许多诊断是不可能的，至少是不可靠的。但是在显微镜下观察的病理学家仍然是最终的决策者。我们都知道，好的病理学家可以对不良的玻片和/或免疫染色的玻片进行正确的诊断，但是如果没有知识和经验，即使是最好的玻片也无法满足要求。对于分子病理学，它是不同的。

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