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首页> 外文期刊>Virulence >Brucella C beta G induces a dual pro- and anti-inflammatory response leading to a transient neutrophil recruitment
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Brucella C beta G induces a dual pro- and anti-inflammatory response leading to a transient neutrophil recruitment

机译：布鲁氏菌CβG诱导促炎和抗发炎双重反应，导致短暂性中性粒细胞募集

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Brucella is the causing agent of a chronic zoonosis called brucellosis. The Brucella -1,2 cyclic glucan (CG) is a virulence factor, which has been described as a potent immune stimulator, albeit with no toxicity for cells and animals. We first used a genome-wide approach to characterize human myeloid dendritic cell (mDC) responses to CG. Transcripts related to inflammation (IL-6, IL2RA, PTGS2), chemokine (CXCR7, CXCL2) and anti-inflammatory pathways (TNFAIP6, SOCS3) were highly expressed in CG-treated mDC. In mouse GMCSF-derived DC, CG triggered the expression of both activation (CXCL2, KC) and inhibition (SOCS3 and TNFAIP6) molecules. We then characterized the inflammatory infiltrates at the level of mouse ear when injected with CG or LPS. CG yielded a lower and transient recruitment of neutrophils compared to LPS. The consequence of these dual pro- and anti-inflammatory signals triggered by CG corresponds to the induction of a controlled local inflammation.
机译：布鲁氏菌是称为人布鲁氏菌病的慢性人畜共患病的病原。布鲁氏菌-1,2，环状葡聚糖（CG）是一种毒性因子，尽管对细胞和动物没有毒性，但已被描述为有效的免疫刺激剂。我们首先使用全基因组方法来表征人类对CG的树突状细胞（mDC）的反应。与炎症相关的转录本（IL-6，IL2RA，PTGS2），趋化因子（CXCR7，CXCL2）和抗炎途径（TNFAIP6，SOCS3）在CG处理的mDC中高度表达。在小鼠GMCSF衍生的DC中，CG触发了激活分子（CXCL2，KC）和抑制分子（SOCS3和TNFAIP6）的表达。然后，我们在注射CG或LPS时在小鼠耳朵的水平上表征了炎症浸润。与LPS相比，CG产生的中性粒细胞降低和短暂募集。由CG触发的这些双重促炎和消炎信号的结果对应于受控局部炎症的诱导。

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