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首页> 外文期刊>Virulence >Approved and novel strategies in diagnostics of rat bite fever and other Streptobacillus infections in humans and animals
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Approved and novel strategies in diagnostics of rat bite fever and other Streptobacillus infections in humans and animals

机译：经批准的新颖策略可用于诊断人和动物的大鼠咬热和其他链球菌感染

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Rat bite fever (RBF), a worldwide occurring and most likely under-diagnosed zoonosis caused by Streptobacillus moniliformis, represents the most prominent disease of Streptobacillus infections. Recently, novel members have been described, from which a reservoir in rats and other animal species and a zoonotic potential can be assumed. Despite regularly published case reports, diagnostics of RBF continues to represent a diagnostic dilemma', because the mostly applied 16S rRNA sequence analysis may be uncertain for proper pathogen identification. Virtually nothing is known regarding prevalence in humans and animal reservoirs. For a realistic assessment of the pathogen's spread, epidemiology and virulence traits, future studies should focus on the genomic background of Streptobacillus. Full genome sequence analyses of a representative collection of strains might facilitate to unequivocally identify and type isolates. Prevalence studies using selective enrichment mechanisms may also enable the isolation of novel strains and candidate species of this neglected group of microorganisms.
机译：鼠咬热（RBF）是世界范围内发生的且最有可能被诊断为莫尼氏链球菌的人畜共患病，是链球菌感染的最主要疾病。近来，已经描述了新颖的成员，由此可以推测大鼠和其他动物物种中的储库和人畜共患病的潜力。尽管定期发表病例报告，RBF的诊断仍然代表着诊断难题，因为最常使用的16S rRNA序列分析可能无法正确鉴定病原体。关于人类和动物水库中的患病率，几乎一无所知。为了对病原体的传播，流行病学和毒力特征进行现实的评估，未来的研究应集中在链球菌的基因组背景上。对代表性菌株的全基因组序列分析可能有助于明确鉴定和分型。使用选择性富集机制的流行病学研究也可能能够分离出这种新型微生物的候选菌株和候选物种。

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