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首页> 外文期刊>Virus Genes >Sequence analysis of morbillivirus CD150 receptor-Signaling Lymphocyte Activation Molecule (SLAM) of different animal species.
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Sequence analysis of morbillivirus CD150 receptor-Signaling Lymphocyte Activation Molecule (SLAM) of different animal species.

机译：麻疹病毒CD150受体-不同动物信号转导淋巴细胞活化分子（SLAM）的序列分析。

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摘要

Signaling Lymphocyte Activation Molecule-SLAM (CD150) molecule has been reported as a putative receptor for most morbilliviruses for their respective host species. In this study, we determined the complete nucleotide sequence of the gene coding for the morbillivirus receptor-SLAM from the four species, namely, goat (Capra hircus), sheep (Ovis aries), Indian cattle (Bos indicus), and buffalo (Bubalus bubalis). The nucleotide (nt) open reading frame sequence of SLAM gene in all the four species studied was 1017 nucleotides in length encoding a polypeptide of 339 amino acids (aa), similar to Bos taurus, but different from canine, human, marmoset, and mouse SLAM, which were 1029, 1008, 1011, and 1032 nts, respectively, in length, and coding for 343, 336, 337, and 344 aa, respectively. Sequence analysis revealed 96.3-98.5% and 92.9-96.8% identities among the four species at the nt and aa level, respectively. Sequence diversity at aa level between various species revealed that the critical functional region of SLAM protein among different species is relatively conserved, thereby facilitating this molecule to act as a receptor for morbillivirus. Phylogenetic relationship based on the aa sequences of SLAM protein revealed that caprine, ovine, cattle, and buffalo fall under a defined cluster but caprine SLAM is more closely related to ovine, followed by bovine.
机译：信号淋巴细胞活化分子-SLAM（CD150）分子已被报道为大多数麻疹病毒各自宿主物种的推定受体。在这项研究中，我们从四个物种（即山羊（Capra hircus），绵羊（Ovis aries），印度牛（Bos indicus）和水牛（Bubalus））中确定了编码麻疹病毒受体-SLAM的基因的完整核苷酸序列。泡）。在所有研究的四个物种中，SLAM基因的核苷酸（nt）开放阅读框序列的长度为1017个核苷酸，编码339个氨基酸（aa）的多肽，类似于金牛座，但不同于犬，人，mar猴和小鼠SLAM的长度分别为1029、1008、1011和1032 nt，分别编码为343、336、337和344aa。序列分析表明，这四个物种在nt和aa水平上分别具有96.3-98.5％和92.9-96.8％的同一性。各种物种之间氨基酸水平的序列多样性表明，不同物种之间SLAM蛋白的关键功能区相对保守，从而促进了该分子充当麻疹病毒的受体。基于SLAM蛋白氨基酸序列的系统发生关系表明，山羊，绵羊，牛和水牛属于确定的簇，但是山羊SLAM与绵羊的关联更紧密，其次是牛。

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