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首页> 外文期刊>Virus Genes >The biological properties of E6 and E7 oncoproteins from human papillomaviruses.
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The biological properties of E6 and E7 oncoproteins from human papillomaviruses.

机译：人类乳头瘤病毒中E6和E7癌蛋白的生物学特性。

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摘要

More than 100 different human papillomavirus (HPV) types have been isolated so far, and they can be sub-grouped in cutaneous or mucosal according to their ability to infect the skin or the mucosa of the genital or upper-respiratory tracts. A sub-group of human mucosal HPVs, referred to as high-risk HPV types, is responsible for approximately 5% of all human cancers, which represents one-third of all the tumours induced by viruses. Epidemiological and biological studies have shown that HPV16 is the most oncogenic type within the high-risk group. Emerging lines of evidence suggest that, in addition to the high-risk mucosal HPV types, certain cutaneous HPVs are involved in skin cancer. HPV-associated cancers are intimately linked to HPV persistence and the accumulation of chromosomal rearrangements. The products of the early genes, E6 and E7, of the high-risk mucosal HPV types play a key role in both events. Indeed, these proteins have developed a number of strategies to evade host immuno-surveillance allowing viral persistence, and to alter cell cycle and apoptosis control, facilitating the accumulation of DNA damage/mutations. Often, the two oncoproteins target the same cellular pathways with different mechanisms, showing a strong synergism in promoting cellular transformation and neutralizing the immune response. Here, we review most of the findings on the biological properties and molecular mechanisms of the oncoproteins E6 and E7 from mucosal and cutaneous HPV types.
机译：迄今为止，已经分离出了100多种不同的人类乳头瘤病毒（HPV）类型，根据它们感染生殖器或上呼吸道的皮肤或粘膜的能力，可以将它们分为皮肤或粘膜亚类。人类粘膜HPV的一个亚组，称为高风险HPV类型，约占所有人类癌症的5％，占病毒诱发的所有肿瘤的三分之一。流行病学和生物学研究表明，HPV16是高危人群中最致癌的类型。越来越多的证据表明，除了高风险的粘膜HPV类型外，某些皮肤HPV也参与皮肤癌。与HPV相关的癌症与HPV持续性和染色体重排的积累密切相关。高风险粘膜HPV类型的早期基因E6和E7的产物在这两种事件中都起着关键作用。实际上，这些蛋白质已经开发出许多策略，以逃避宿主的免疫监视，从而实现病毒的持久性，并改变细胞周期和细胞凋亡控制，从而促进DNA损伤/突变的积累。通常，两种癌蛋白以不同的机制靶向相同的细胞途径，在促进细胞转化和中和免疫应答方面显示出强大的协同作用。在这里，我们综述了黏膜和皮肤HPV类型癌蛋白E6和E7的生物学特性和分子机制的大部分发现。

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