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首页> 外文期刊>Virus Genes >Genetic reassortment between high-virulent and low-virulent Dobrava-Belgrade virus strains.
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Genetic reassortment between high-virulent and low-virulent Dobrava-Belgrade virus strains.

机译：高毒力和低毒力的多布拉瓦-贝尔格莱德病毒株之间的遗传重配。

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摘要

The tri-segmented RNA genome of hantaviruses facilitates genetic reassortment by segment swapping when cells are co-infected with different virus strains. We found efficient in vitro reassortment between members of two different genetic lineages of the Dobrava-Belgrade virus species, the weakly virulent DOBV-Aa and highly virulent DOBV-Af. In all reassortants, S and L segments originated from the same parental strain, and only the M segment was exchanged. To identify functional differences between the parental strains DOBV-Aa and DOBV-Af in cell culture and to compare them with the reassortants, we studied elements of the innate immunity in virus-infected cells. The contrasting phenotypes of the parental viruses were maintained by the reassortants carrying the respective S and L segments of the parental virus and were not influenced by the origin of the M segment.
机译：当细胞与不同病毒株共同感染时，汉坦病毒的三段RNA基因组通过片段交换促进遗传重配。我们发现Dobrava-Belgrade病毒物种的两个不同遗传谱系成员（弱毒DOBV-Aa和高毒DOBV-Af）之间的有效体外重配。在所有重配物中，S和L片段均来自同一亲本菌株，只有M片段被交换。为了确定亲代菌株DOBV-Aa和DOBV-Af在细胞培养中的功能差异，并将它们与重配体进行比较，我们研究了病毒感染细胞中先天免疫的成分。携带亲本病毒的各个S和L区段的重配体维持了亲本病毒的相反表型，并且不受M区段的起源的影响。

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