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首页> 外文期刊>Veterinary Surgery >Additional local therapy with primary re-excision or radiation therapy improves survival and local control after incomplete or close surgical excision of mast cell tumors in dogs.
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Additional local therapy with primary re-excision or radiation therapy improves survival and local control after incomplete or close surgical excision of mast cell tumors in dogs.

机译：犬肥大细胞瘤手术切除不完全或严密切除后，采用原发再切除或放射治疗的其他局部治疗可改善生存率和局部控制。

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Objective: To compare survival and local recurrence outcomes in dogs with mast cell tumors with incomplete or close margins treated with primary re-excision or radiation therapy of the primary site versus no additional local therapy. Study Design: Retrospective case series. Animals: Dogs (n=64). Methods: Outcomes of canine mast cell tumor cases that had incomplete or close surgical resection and presented to the Ontario Veterinary College Health Sciences Centre (2001-2010) were evaluated after additional local therapy (primary re-excision or radiation therapy) or no additional local therapy (comparison). Follow-up was performed through evaluation of medical records and telephone contact with referring veterinarians and owners. Results: Tumors (n=70) in 64 dogs were studied. Median survival times for the primary re-excision (2930 days) and radiation therapy (2194 days) groups were significantly longer than for the comparison (710 days) group. Local recurrence occurred in 13% of the re-excision group, 8% of the radiation therapy group, and 38% of the comparison group. Although local recurrence rate was not statistically significant for the re-excision group, time to local recurrence was statistically longer for both the re-excision and radiation groups. Adjunctive chemotherapy was not associated with improved survival or local control. Conclusion/Clinical relevance: There is significant improvement in survival and duration of local control when additional local therapy is performed after incomplete or close resection of mast cell tumors. These follow-up therapies should be recommended to owners when mast cell tumors are incompletely or closely resected.
机译：目的：比较用原发部位再行切除或放射治疗与不进行其他局部治疗的肥大细胞瘤犬，其边缘不完全或紧密闭合的存活率和局部复发结果。研究设计：回顾性病例系列。动物：狗（n = 64）。方法：对不完整或接近手术切除的犬肥大细胞肿瘤病例的结果进行了评估，并在接受了额外的局部治疗（主要是再次切除或放射治疗）或未进行额外的局部治疗后提交给安大略兽医学院卫生科学中心（2001-2010）治疗（比较）。通过评估病历并与推荐的兽医和主人进行电话联系来进行随访。结果：研究了64只狗的肿瘤（n = 70）。初次再次切除（2930天）和放射治疗（2194天）组的中位生存时间明显长于比较组（710天）。局部复发发生在再切除组的13％，放疗组的8％，比较组的38％。尽管再切除组的局部复发率在统计学上不显着，但再切除组和放疗组的局部复发时间在统计学上更长。辅助化疗与改善生存率或局部控制无关。结论/临床意义：肥大细胞瘤切除不完全或紧密切除后再进行局部治疗可显着改善生存率和局部控制持续时间。当肥大细胞肿瘤未完全切除或紧密切除时，应向所有者推荐这些后续治疗方法。

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